A, PTEN loss signature score in resected SQCLC brain metastases.

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A, PTEN loss signature score in resected SQCLC brain metastases. A, PTEN loss signature score in resected SQCLC brain metastases. Values plotted to the right are more strongly correlated with PTEN loss. Expression of PIK3CA and PTEN from individual samples in the TCGA SQCLC analysis is plotted for reference, confirming a trend toward decreased PTEN expression and increased PIK3CA expression and signature scores consistent with PTEN loss. PTEN signature activities in the brain metastases were compared with the signatures in the TCGA primary tumors using a one-sided Wilcoxon rank-sum test. B, prometastatic WNT gene signature score in resected SQCLC brain metastases. Values plotted to the right are more strongly correlated with WNT activity. Expression of HOXB9 and LEF1, key promoters of the brain metastatic process in lung adenocarcinomas, from individual samples in the TCGA SQCLC analysis is plotted as an SQCLC-specific reference. WNT signature activities in the brain metastases were compared with the signatures in the TCGA primary tumors using a one-sided Wilcoxon rank-sum test. C, plasminogen activator (PA) inhibitor serpin gene expression levels from the TCGA SQCLC analysis and SQCLC brain metastases. There was no substantial increase in PA serpin expression in the brain metastases versus early stage tumors from TCGA. LUSC, lung squamous cell carcinoma. Paul K. Paik et al. Cancer Discovery 2015;5:610-621 ©2015 by American Association for Cancer Research