Fig. 1 Constitutive NF-κB activation in the lentivirus-induced GBM mouse model. Constitutive NF-κB activation in the lentivirus-induced GBM mouse model.

Slides:

Advertisements

Similar presentations

Glioma-derived soluble factor(s) enhance IL-10 signaling.

Advertisements

CD4+ICOS+IL-4+ TFH cells are sparse in human SLOs.

Zika virus impairs growth in human neurospheres and brain organoids

Fig. 3. Obese IFN-γ−/− mice develop accelerated NAFLD with fibrosis.

Fig. 6. Treatment with a DLK inhibitor is neuroprotective and reverses stress-induced gene expression changes. Treatment with a DLK inhibitor is neuroprotective.

Intravenous delivery of reovirus to primary and secondary brain tumors

Fig. 5. Antitumor efficacy of ERY974 in immunocompetent human CD3 transgenic mice. Antitumor efficacy of ERY974 in immunocompetent human CD3 transgenic.

Fluorescence-stained images and respective bright-field images of mouse spleen tissue sections area investigated using Raman spectroscopy. Fluorescence-stained.

Figure 2 Brain-infiltrating immune cells mainly consist of CD8+ memory T cells Immunofluorescence staining of brain-infiltrating immune cells. Brain-infiltrating.

Fig. 1. CD31 is present throughout the human renal vasculature.

Toll-Like Receptor 4 Has an Essential Role in Early Skin Wound Healing

CCN1, a Pro-Inflammatory Factor, Aggravates Psoriasis Skin Lesions by Promoting Keratinocyte Activation Yue Sun, Jie Zhang, Zhou Zhou, Pinru Wu, Rongfen.

Alveolar lymphangiogenesis is a feature of idiopathic pulmonary fibrosis (IPF). a) Tissue sections reacted with anti-D2-40 (brown) and anti-CD34 (red)

ZIKV infection induces DNA methylation changes in human cerebral organoid-derived astrocytes, neurons, and neural progenitor cells. ZIKV infection induces.

Correlation of mouse gene expression with bacterial gene expression.

SIRT1 DAPI SIRT1 DAPI DAPI

PAAND is driven by local inflammasome activation and IL-1β production

Loss of Keap1 contributes to LSCC pathogenesis by activating the NRF2–ROS pathway. Loss of Keap1 contributes to LSCC pathogenesis by activating the NRF2–ROS.

Fig. 1 CSPG4 is expressed in GBM specimens and GBM-NS and associated with more aggressive disease. CSPG4 is expressed in GBM specimens and GBM-NS and associated.

Effectively regenerating livers transiently accumulate proliferative IGF2BP3-positive cells. Effectively regenerating livers transiently accumulate proliferative.

Somatic Rearrangement in B Cells: It’s (Mostly) Nuclear Physics

Fig. 3 CSF1 is expressed in human melanoma.

In Vivo Tracking of Mesechymal Stem Cells Using Fluorescent Nanoparticles in an Osteochondral Repair Model Jong Min Lee, Byung-Soo Kim, Haeshin Lee,

Correlation of reovirus RNA/protein with proliferating tumor cells

Neutrophil recruitment to the colonic lamina propria depends on CD4+ T cells. Neutrophil recruitment to the colonic lamina propria depends on CD4+ T cells.

Blood Tfr cells show expression of follicular and regulatory markers.

IL-10R-deficient macrophages secrete IL-23, inducing IL-22 secretion by ILC3 and TH17 cells. IL-10R-deficient macrophages secrete IL-23, inducing IL-22.

Fig. 3 Conserved genomic association of PRC1 activity in different leukemic cells. Conserved genomic association of PRC1 activity in different leukemic.

Fig. 2 Endurance exercise up-regulates TERRA in human muscle.

AhR activation alters gene expression in human monocyte-derived DCs

Fig. 3 Intrarenal and RDLN lymphangiogenesis accompanied by lymphocyte expansion in the kidney, RDLN, and spleen. Intrarenal and RDLN lymphangiogenesis.

Fig. 4 p100/TSN enables E2F1 to interact with alternatively spliced transcripts. p100/TSN enables E2F1 to interact with alternatively spliced transcripts.

Fig. 5 E2F1 also interacts with alternatively spliced transcripts from the MECOM gene. E2F1 also interacts with alternatively spliced transcripts from.

Global analysis of RV[S/T]F motif phosphorylation during mitosis.

Morphologic changes induced in immortalized human podocytes after treatment with TGF-β1 (10 ng/mL, right) for 3 days when compared with control cells (left),

Loss of BAP1 blocks T cell differentiation at the DN3 stage in vitro.

Fig. 1. DEL-1 is expressed by human and mouse osteoclasts.

Fig. 3 The rs risk enhancer is a hub for intrachromosomal and interchromosomal interactions. The rs risk enhancer is a hub for intrachromosomal.

Fig. 1 Genes up-regulated in Zic5 KO cells correlate with the increased glycolytic state. Genes up-regulated in Zic5 KO cells correlate with the increased.

Fig. 2 Expressions of cll, abd-A, and Abd-B by qRT-PCR.

S-Affs colocalize with SUMO in mammalian cells.

Fig. 1 IDH3α expression is elevated in human-derived gliomas.

Fig. 5 n-HA regulates gene expressions related to tumor suppression, calcium homeostasis, and immune response. n-HA regulates gene expressions related.

Fig. 1. Matrix stiffness sensitizes myofibroblasts to apoptosis induced by inhibition of their mechanotransduction pathways. Matrix stiffness sensitizes.

Inflammation Mediated by JNK in Myeloid Cells Promotes the Development of Hepatitis and Hepatocellular Carcinoma Myoung Sook Han, Tamera Barrett, Michael.

Fig. 1 Deficient CD73 and CD39 expressions and extracellular adenosine concentration in BM of OVX animals. Deficient CD73 and CD39 expressions and extracellular.

Functional assessment of NF-κB activation in SKBR3 cells.

Fig. 4 Effects of hematopoietic restoration of TLR9 on adipose tissue inflammation and insulin resistance. Effects of hematopoietic restoration of TLR9.

Fig. 5. Vascularization of human liver seed grafts.

Targeting p53-dependent stem cell loss for intestinal chemoprotection

Circulating leukocytes are undetectable in blood vessels of solid tumors in RIP1-Tag2 mice even after IL-15/IL-15Rα complex treatment. Circulating leukocytes.

Fig. 1 Dcr-2 is required for Toll signaling in Drosophila S2 cells.

Microfluidic platform for cell phenotype and gene function analysis

Fig. 6 Antitumor effect on tumor growth and pulmonary metastasis of CSSD-9 in vivo. Antitumor effect on tumor growth and pulmonary metastasis of CSSD-9.

Enrichment and detection of CTCs from orthotopic xenograft models of GBM. A, immunohistologic analysis of coronal sections showing mCherry expressing GBM8.

Fig. 4 S. elongatus therapy does not elicit a pathologic immune response nor persist in tissue long-term. S. elongatus therapy does not elicit a pathologic.

ROR1 expression is inversely correlated to Wnt5A/ROR2.

Fig. 5 Proportions of EpCAM+ systemic tumor cells correlate with the clinical outcome of patients with MBC. Proportions of EpCAM+ systemic tumor cells.

Fig. 5 Distributions of cell nuclear area values and internuclear distances in the breast tumor specimens (Figs. 3 and 4), where bin interval = 8 and n.

CD36 expression in tissue adjacent and distal to the tumor.

Fig. 5 The complex of antibody and dye can afford to target imaging in the NIR-II window. The complex of antibody and dye can afford to target imaging.

Fig. 2 Dcr-2 is required for Toll activation in adult flies.

Fig. 4 Acoustophoretic printing of food, optical, biological, and electrically conductive materials. Acoustophoretic printing of food, optical, biological,

Fig. 2 Combined transcriptome profiling, ChIP-seq, and ATAC-seq analysis identifies 14 highly plausible direct targets of Runx. Combined transcriptome.

Fig. 2 hTERT induces expression of heat shock protein genes through HSF1 and interacts with Hsp70-1. hTERT induces expression of heat shock protein genes.

Spontaneous PD in DRB1*04:01 mice.

Fig. 5 Enhancers and super-enhancers identified in various brain cell populations. Enhancers and super-enhancers identified in various brain cell populations.

Fig. 5 CD19-tPSMA(N9del) CAR T cell numbers in mouse and human.

Fig. 4 Rotavirus induces the type I IFN pathway and release of ATP by tumor cells. Rotavirus induces the type I IFN pathway and release of ATP by tumor.

Cxxc1-deficient TH17 cells exhibit a Treg cell–like expression profile

Presentation transcript:

Fig. 1 Constitutive NF-κB activation in the lentivirus-induced GBM mouse model. Constitutive NF-κB activation in the lentivirus-induced GBM mouse model. (A) Heat map of the RNA-Seq analysis of NF-κB target genes (list of 150 genes; http://bioinfo.lifl.fr/NF-KB/) comparing normal brain tissue (NBT; n = 3), HRas-shp53–induced GBM tumors (n = 5), and 005 tumors (n = 3). (B) qRT-PCR analysis of six representative NF-κB target genes in NBT and tumor samples. (C) Immunofluorescence staining of CD44 (red) and Nestin (white) in tumor sections shows MES subtype (left) and nuclear p65 (white) staining, and IL-6 (red) confirms NF-κB activation in these tumors (right). Arrows point to p65 staining in the nucleus of cells. N, normal tissue; T, tumor; PLAU, plasminogen activator, urokinase; SERPINE1, serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; CCL2, chemokine (C-C motif) ligand 2; DAPI, 4′,6-diamidino-2-phenylindole. Dinorah Friedmann-Morvinski et al. Sci Adv 2016;2:e1501292 Copyright © 2016, The Authors