A, Hippocampal protein levels of IL-6 in LD and DD mice treated with PDTC, ASA, or saline controls. A, Hippocampal protein levels of IL-6 in LD and DD.

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Presentation transcript:

A, Hippocampal protein levels of IL-6 in LD and DD mice treated with PDTC, ASA, or saline controls. A, Hippocampal protein levels of IL-6 in LD and DD mice treated with PDTC, ASA, or saline controls. B, Quantitative evaluation of BrdU+ cells in the hippocampal subgranular zone in PDTC-treated and saline control DD mice. C, Representative images of immunohistochemical analysis of the hippocampal dentate gyrus depicting BrdU+ cells (light red) in the subgranular zone in PDTC-treated and saline control DD mice. D, E, per2 (D) and npas2 (E) hippocampal protein levels of IL-6 in LD and DD mice treated with PDTC, ASA, or saline controls. Protein levels are ratios of optical densities. Values from the DD group are normalized to those of the LD saline controls. All data are displayed as mean ± SEM. Significant differences refer to main effects of light and post hoc comparisons performed subsequent to ANOVA analysis for evaluation of pairwise differences (see Results). *p < 0.05, **p < 0.01, ***p < 0.001. Francisco J. Monje et al. J. Neurosci. 2011;31:9075-9083 ©2011 by Society for Neuroscience