A, B, Transcription factor p65 (A) and p50 (B) DNA binding activity in hippocampal nuclear extracts of LD and DD mice. A, B, Transcription factor p65 (A) and p50 (B) DNA binding activity in hippocampal nuclear extracts of LD and DD mice. Photometric absorbance measurements of the DD group are normalized to those of the LD controls and depicted as fold changes. C, D, Immobility (percentage of total time) in the forced-swim test (C) and the tail-suspension test (D) in DD IL-6 KO and WT mice. All data are displayed as mean ± SEM. *p < 0.05, ***p < 0.001. Francisco J. Monje et al. J. Neurosci. 2011;31:9075-9083 ©2011 by Society for Neuroscience