Population pharmacokinetics of tobramycin administered thrice daily and once daily in children and adults with cystic fibrosis D.J. Touw, A.J. Knox,

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Population pharmacokinetics of tobramycin administered thrice daily and once daily in children and adults with cystic fibrosis D.J. Touw, A.J. Knox, A. Smyth Journal of Cystic Fibrosis Volume 6, Issue 5, Pages 327-333 (September 2007) DOI: 10.1016/j.jcf.2006.12.007 Copyright © 2007 European Cystic Fibrosis Society. Terms and Conditions

Fig. 1 Relationship between volume of distribution per kg body weight and age. Diamonds: paediatric patients receiving tobramycin once daily, squares: paediatric patients receiving tobramycin three times daily, triangles: adult patients receiving tobramycin once daily and crosses: adult patients receiving tobramycin three times daily. Journal of Cystic Fibrosis 2007 6, 327-333DOI: (10.1016/j.jcf.2006.12.007) Copyright © 2007 European Cystic Fibrosis Society. Terms and Conditions

Fig. 2 Relationship between renal elimination rate per ml/min/1.73 m2 creatinine clearance and age. Diamonds: paediatric patients receiving tobramycin once daily, squares: paediatric patients receiving tobramycin three times daily, triangles: adult patients receiving tobramycin once daily and crosses: adult patients receiving tobramycin three times daily. Journal of Cystic Fibrosis 2007 6, 327-333DOI: (10.1016/j.jcf.2006.12.007) Copyright © 2007 European Cystic Fibrosis Society. Terms and Conditions