Volume 135, Issue 5, Pages 1591-1600.e1 (November 2008) Inhibitory Control Test for the Diagnosis of Minimal Hepatic Encephalopathy  Jasmohan S. Bajaj, Muhammad Hafeezullah, Jose Franco, Rajiv R. Varma, Raymond G. Hoffmann, Joshua F. Knox, Darrell Hischke, Thomas A. Hammeke, Steven D. Pinkerton, Kia Saeian  Gastroenterology  Volume 135, Issue 5, Pages 1591-1600.e1 (November 2008) DOI: 10.1053/j.gastro.2008.07.021 Copyright © 2008 AGA Institute Terms and Conditions

Figure 1 (A) The individual value plot of lures in cirrhotic patients with and without MHE shows 88% sensitivity and 77% specificity for the diagnosis of MHE using a cut off of 5 lures and above. SPT was used as the gold standard for the diagnosis of MHE. The total number of lures in the ICT is 40. MHE, minimal hepatic encephalopathy; SPT, standard psychometric battery. (B) The receiver operating characteristic curve for the ICT lure response for the diagnosis of MHE using SPT as a gold standard showed that an area under the curve was 0.902. There was no significant contribution of ICT targets, lure, and target reaction time to this area under the curve on logistic regression. MHE, minimal hepatic encephalopathy; SPT, standard psychometric battery. Gastroenterology 2008 135, 1591-1600.e1DOI: (10.1053/j.gastro.2008.07.021) Copyright © 2008 AGA Institute Terms and Conditions

Supplementary Figure 1 Lure response rate before and after TIPS placement showed a significant worsening in lure response rate after TIPS placement. Three patients developed OHE and were re-tested while they were on lactulose. Total number of lures is 40. Gastroenterology 2008 135, 1591-1600.e1DOI: (10.1053/j.gastro.2008.07.021) Copyright © 2008 AGA Institute Terms and Conditions

Supplementary Figure 2 There was a significant improvement in ICT lures after probiotic yogurt supplementation in a randomized controlled trial. The patients randomized to the no-treatment group did not show any significant difference in lure response rate before and after the trial. Solid lines indicate patients randomized to probiotic yogurt and dotted lines were patients randomized to the no-treatment group. Gastroenterology 2008 135, 1591-1600.e1DOI: (10.1053/j.gastro.2008.07.021) Copyright © 2008 AGA Institute Terms and Conditions