Nerve injury induces mechanical hypersensitivity.

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Presentation transcript:

Nerve injury induces mechanical hypersensitivity. Nerve injury induces mechanical hypersensitivity. In C57BL/6J mice, unilateral sciatic nerve compression induces an ipsilateral long-lasting mechanical hypersensitivity which lasts ∼11 weeks. After this period, mechanical thresholds return back to sham levels spontaneously. Sham, n = 24; Cuff, n = 24. Data are mean ± SEM. ***p < 0.001. PWT, Paw withdrawal threshold. Jim Sellmeijer et al. J. Neurosci. 2018;38:3102-3115 ©2018 by Society for Neuroscience