NanoString gene expression analysis.

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Epistasis Epistasis – When one gene affects the phenotypic expression of a second gene Examples of this are in mice – Mice have one gene for the presence/absence.

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NanoString gene expression analysis. NanoString gene expression analysis. A, Counts for each of the nine H2-Mv genes in ΔH2Mv and WT mice in a 129/Sv background at 3 weeks. Genes are arranged according to their position on chromosome 17. Note that the absolute values of counts in WT mice cannot be compared among H2-Mv genes due to differences in the efficiency of probe recovery and detection. B, M-values plotted for the 37 informative Vmn2r genes in CodeSet Chanel at 3 weeks. M is the log2 of the fold change of counts in ΔH2Mv mice over the counts in WT mice. Vmn2r genes are arranged per family and then numerically within a family. Families are depicted in different colors. The black stipple line corresponds to an M value of 0, which represents no change in ΔH2Mv mice compared with WT mice. There are no differentially expressed Vmn2r genes. C, Counts for each of the nine H2-Mv genes in ΔH2Mv and WT mice in a C57BL/6 background at 8 weeks. D, M-values for the 36 informative Vmn2r genes at 8 weeks. Differentially expressed (DE) genes are indicated by filled squares and their names are annotated. Trese Leinders-Zufall et al. J. Neurosci. 2014;34:5121-5133 ©2014 by Society for Neuroscience