CD11bhighCD27high conventional NK cells are converted into MDSCs

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CD11bhighCD27high conventional NK cells are converted into MDSCs CD11bhighCD27high conventional NK cells are converted into MDSCs. Among each maturation state (CD11blowCD27low, CD11blowCD27high, CD11bhighCD27high, and CD11bhighCD27low), Lin−CD122+NKp46+/NK1.1+ CD11bhighCD27high NK cells were sorted from tumor-bearing BAL... CD11bhighCD27high conventional NK cells are converted into MDSCs. Among each maturation state (CD11blowCD27low, CD11blowCD27high, CD11bhighCD27high, and CD11bhighCD27low), Lin−CD122+NKp46+/NK1.1+ CD11bhighCD27high NK cells were sorted from tumor-bearing BALB/c (A) and C57BL/6 mice (B), respectively. Sorted cells were incubated with GM-CSF or IL-2/GM-CSF for 5 days and Gr1+CD11b+ cell induction and CD122, NKp46, or NK1.1 expression were analyzed (the other 3 populations of NK cells hardly responded to the GM-CSF, data not shown). The data are representative of 3-independent experiments. Shaded, isotype control. C, hematoxylin and eosin staining of CD11bhighCD27high NK cells cultured with GM-CSF or IL-2/GM-CSF for 5 days. Magnification, ×400. D, CD11bhighCD27high NKp46+ cells from tumor-bearing mice were incubated with 20 ng/mL of GM-CSF ± IL-2 or IL-15. The numbers in the parenthesis indicate the concentration (ng/mL). The numbers in the plot indicate the percentage of gated cells. Young-Jun Park et al. Cancer Res 2013;73:5669-5681 ©2013 by American Association for Cancer Research