Percent binding of cross-reactive antibodies from parallel studies in insulin-treated patients with type 1 or type 2 diabetes. Percent binding of cross-reactive antibodies from parallel studies in insulin-treated patients with type 1 or type 2 diabetes. Mean and 95% CIs over time are shown. The vertical dotted line separates parent and extension studies. The inset graph is the fitted quadratic random mixed model. S. Edwin Fineberg et al. Dia Care 2003;26:89-96 ©2003 by American Diabetes Association