Change in bone in patients who were treated with calcium or sevelamer.

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Change in bone in patients who were treated with calcium or sevelamer. Change in bone in patients who were treated with calcium or sevelamer. In a secondary analysis of the thoracic spine from the Treat to Goal study, the attenuation, which is a measure of calcium content, was assessed in paired (pre-post) electron-beam computed tomography scans. Compared with sevelamer-treated patients (▪), calcium-treated patients (□) showed a decrease in thoracic vertebral trabecular (cancellous) bone attenuation (P = 0.01) and a trend toward decreased cortical bone attenuation. More than 30% of calcium-treated patients experienced a 10% or more decrease in trabecular (cancellous) and cortical bone attenuation. Reprinted from reference (46), with permission. Sharon M. Moe, and Glenn M. Chertow CJASN 2006;1:697-703 ©2006 by American Society of Nephrology