V. Lazarevic, S. Manzano, N. Gaïa, M. Girard, K. Whiteson, J. Hibbs, P

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Presentation transcript:

Effects of amoxicillin treatment on the salivary microbiota in children with acute otitis media V. Lazarevic, S. Manzano, N. Gaïa, M. Girard, K. Whiteson, J. Hibbs, P. François, A. Gervaix, J. Schrenzel Clinical Microbiology and Infection Volume 19, Issue 8, Pages e335-e342 (August 2013) DOI: 10.1111/1469-0691.12213 Copyright © 2013 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 1 Relative abundance of seven major phyla across different studies of the salivary microbiome. Data obtained for different individuals (and different time-points if available) were averaged for each study except that of Keijser et al. 24 in which individual non-bar-coded amplicon libraries were pooled in equimolar amounts before sequencing. 'A' and 'C' correspond to the treated and untreated group of children analysed in this study, respectively. 'Children/adolescents AVG' and 'Adults AVG' were obtained by averaging data from the relevant studies. Clinical Microbiology and Infection 2013 19, e335-e342DOI: (10.1111/1469-0691.12213) Copyright © 2013 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 2 Principal coordinate analysis of unweighted UniFrac distance matrices. Blue squares, orange circles and grey-contour triangles correspond to samples taken at the time of the first, second and third visit, respectively. The area comprising samples taken at the time of the first and second visit for treated (a) and control (b) subjects are blue and orange shaded, respectively. Clinical Microbiology and Infection 2013 19, e335-e342DOI: (10.1111/1469-0691.12213) Copyright © 2013 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 3 Average within-subject and between-subject unweighted UniFrac distances. 'A' and 'C' correspond to the treated and untreated groups of children. Standard error bars are given and the Mann–Whitney U-test significance is indicated as follows: *p <0.05; **p <0.01, *** p<0.001. Clinical Microbiology and Infection 2013 19, e335-e342DOI: (10.1111/1469-0691.12213) Copyright © 2013 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 4 Richness and diversity indices of the salivary bacterial communities. Margalef richness (d) and Shannon diversity (H') indices were calculated for the six groups of samples. Each sample was normalized to 283 sequences before analysis. Average values and standard error bars are presented. The statistical analysis was Wilcoxon signed-rank test. Clinical Microbiology and Infection 2013 19, e335-e342DOI: (10.1111/1469-0691.12213) Copyright © 2013 European Society of Clinical Infectious Diseases Terms and Conditions