Signal characteristics of PML Signal characteristics of PML.A and B, Axial MR studies show low-signal-intensity lesions on T1-weighted (533/25/1) image (A) and hyperintense lesions on T2-weighted (2000/80/1) image (B) in the centrum semiovale bilaterally, subcortical white matter, and c... Signal characteristics of PML.A and B, Axial MR studies show low-signal-intensity lesions on T1-weighted (533/25/1) image (A) and hyperintense lesions on T2-weighted (2000/80/1) image (B) in the centrum semiovale bilaterally, subcortical white matter, and corpus callosum. Note the asymmetrical white matter involvement, with the left cerebral hemispheric white matter more severely affected. M. Judith Donovan Post et al. AJNR Am J Neuroradiol 1999;20:1896-1906 ©1999 by American Society of Neuroradiology