SDF-1/CXCR4 axis is involved in CD133+ tumor cell metastasis toward a lymphatic metastasis niche. SDF-1/CXCR4 axis is involved in CD133+ tumor cell metastasis.

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SDF-1/CXCR4 axis is involved in CD133+ tumor cell metastasis toward a lymphatic metastasis niche. SDF-1/CXCR4 axis is involved in CD133+ tumor cell metastasis toward a lymphatic metastasis niche. A–C, 3 weeks after B16/F10 melanoma cells were implanted into C57BL/6J mice, the tumors, and ALNs were harvested. A, images showing differences in SDF-1 expression on LYVE-1+ lymphatic vessels in control and metastasized ALNs. Scale bars, 50 μm. B, FACS analysis of CXCR4 expression on CD133+ cells in tumor. C, images showing CD133+/MelanA+ cells coexpressing CXCR4 in ALN (arrowheads). Each group, n = 6. Scale bar, 20 μm. D–H, 2 weeks after 1 × 103 of sorted CXCR4+/CD133+ and CXCR4− /CD133+ cells were implanted into C57BL/6J mice, tumor volumes were measured, and the tumors and ALNs were sampled. D and E, photograph showing the gross features of tumor formation (D) and quantification of tumor size (E). F, photograph showing gross features of metastasized ALN (left) and quantification of LN size (right). *, P < 0.05 versus CXCR4−/CD133+ cells. G and H, images showing differences CD133+/MelanA+ cell (white arrowheads) metastasis to ALN (G) and quantification of the number of CD133+/MelanA+ cells in the mid-sectioned ALN (H). Scale bars, 20 μm. Each group, n = 6. *, P < 0.05 versus CXCR4−/CD133+ cells. Minah Kim et al. Cancer Res 2010;70:10411-10421 ©2010 by American Association for Cancer Research