Gli3 expression is reduced in the forebrain of Pdn/Pdn mutants.

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Gli3 expression is reduced in the forebrain of Pdn/Pdn mutants. Gli3 expression is reduced in the forebrain of Pdn/Pdn mutants. A–H, Gli3 in situ hybridization on coronal sections through the forebrain of E10.5 (A, D) and E12.5 (B, C, E, F) wild-type (wt; A–C) and Pdn/Pdn (D–F) embryos. Gli3 mRNA levels are clearly reduced in Pdn mutants but the overall expression pattern is conserved. The arrowheads in B, C, F, and G mark Gli3 expression in the MGE mantle zone. I, Gli3 Western blot analysis with E12.5 ventral telencephalic extracts. In Pdn mutant extract, Gli3 activator and repressor forms are present at reduced level but are absent in XtJ mutants. The asterisk indicates an additional Gli3-specific 85 kDa protein. An unspecific 50 kDa band was used as a loading control. J, Quantification of Western blot data. Asterisk (*) denotes statistically significant changes with p ≤ 0.05. ctx, Cortex; DT, dorsal thalamus; zli, zona limitans intrathalamica. Dario Magnani et al. J. Neurosci. 2010;30:13883-13894 ©2010 by Society for Neuroscience