Fig. 4. A potential common pathogenic pathway for ALS/FTD.

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Volume 60, Issue 2, Pages (October 2015)

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ALS disease pathology and proposed disease mechanisms.

Fig. 3. Structure of ALS-associated RNA binding proteins.

Basic design concept of human mimetic humanoid.

TPAD controller schematic and testing for WPC.

TPAD controller performance for three force components.

Three different types of transfer functions with a codomain of [0,1].

TPAD training protocol.

Workspace comparison of Delta robots.

Protein sequence alignment of the NS3 helicase–encoding region of 63 flaviviruses demonstrates conservation of a KIR2DS2-binding peptide. Protein sequence.

Comparison of repertoire distributions to baseline.

Fig. 7 Correlation of NHP and human ISGs.

Fig. 5 Correlation of RNA expression and protein abundance.

Protein sequence alignment of the NS3 helicase–encoding region of 63 flaviviruses demonstrates conservation of a KIR2DS2-binding peptide. Protein sequence.

Online verification using reachable occupancies.

Fig. 2 Whisker deprivation accelerates and enhances behavioral recovery after right S1FP photothrombosis. Whisker deprivation accelerates and enhances.

Fig. 2 Global production, use, and fate of polymer resins, synthetic fibers, and additives (1950 to 2015; in million metric tons). Global production, use,

Fig. 3 ROC curves of mCCNA1 and mVIM assayed in esophageal cytology brushings from control normal-appearing GE junctions versus BE and EAC cases. ROC curves.

Fig. 3 Conditionally expressed CAR using Notch as a signal induction and response pathway system. Conditionally expressed CAR using Notch as a signal induction.

Fig. 2 Preserved long-term functionality of the TEHVs over 1-year follow-up as assessed by ICE and cardiac MRI flow measurements. Preserved long-term functionality.

Fig. 1 Map of water stress and shale plays.

In vivo release of doxycycline hyclate from the GRS in a swine model

Fig. 4 Resynthesized complex boronic acid derivatives based on different scaffolds on a millimole scale and corresponding yields. Resynthesized complex.

Fig. 2 The glucose binding and charge-switch study.

Fig. 3 Glucose- and structure-dependent insulin release.

Fig. 1 Product lifetime distributions for the eight industrial use sectors plotted as log-normal probability distribution functions (PDF). Product lifetime.

Underwater observatory.

Fig. 1 BMS binds to the pseudokinase domain of TYK2 and inhibits receptor-mediated TYK2 activation and downstream phosphorylation events in human.

BMS blocks functional responses in primary immune cells driven by IFNα

Fig. 3 Identification of KEECs that increase KCC2 expression in human RTT neurons. Identification of KEECs that increase KCC2 expression in human RTT neurons.

Fig. 1 Distribution of total and fake news shares.

Altered Ribostasis: RNA-Protein Granules in Degenerative Disorders

Fig. 2 2D QWs of different propagation lengths.

Fig. 2. Mutational signature exposures in Taiwan HCCs and summary of AA signature mutations. Mutational signature exposures in Taiwan HCCs and summary.

AEGIS autonomous targeting process.

Fig. 1 Boronic acid–rich dendrimer with robust efficiency in cytosolic protein delivery. Boronic acid–rich dendrimer with robust efficiency in cytosolic.

Fig. 5 Schematic phase diagrams of Ising spin systems and Mott transition systems. Schematic phase diagrams of Ising spin systems and Mott transition systems.

Fig. 3 Local Maraba treatment of TNBC tumors provides long-term systemic protection. Local Maraba treatment of TNBC tumors provides long-term systemic.

Fig. 1 Average contribution (million metric tons) of seafood-producing sectors, 2009–2014. Average contribution (million metric tons) of seafood-producing.

Representative CT and PET/CT images of three patients with NSCLCs

Fig. 3 Production of protein and Fe(II) at the end of growth correlated with increasing concentrations of ferrihydrite in the media that contained 0.2.

Fig. 1 Crohn’s disease association within the LRRK2 locus.

Fig. 2 Effect of CSF sTREM2– and CSF sTREM2–to–p-tau181 ratio on changes in cognition. Effect of CSF sTREM2– and CSF sTREM2–to–p-tau181 ratio on changes.

Depicting brighter possibilities for treating blindness

Fig. 5. Vascularization of human liver seed grafts.

Tissue architecture affects function of expanded liver seed grafts

Fig. 3 Mmp-2−/− mice are protected from obesity and leptin resistance.

Fig. 2 Images of the optical field at transmitter and receiver.

Analysis of A-to-I RNA edits found in transcriptome-wide RNA-seq

Fig. 5 Comparison of the liquid products generated from photocatalytic CO2 reduction reactions (CO2RR) and CO reduction reactions (CORR) on two catalysts.

Schematic of the proposed brain-controlled assistive hearing device

Bio-AMS enhances the activity of rifampicin and ethambutol in vitro

Fig. 1 Location of the Jirzankal Cemetery.

Fig. 2 Increasing KLF17, CDH1, and LASS2 expression reduced malignant progression and promoted apoptosis of tumor cells. Increasing KLF17, CDH1, and LASS2.

Fig. 1 Relevance of therapies for treating retinal degeneration and stage of disease. Relevance of therapies for treating retinal degeneration and stage.

Fig. 5. High burdens of AA signature mutations and predicted immunogenicity in Taiwan HCCs. High burdens of AA signature mutations and predicted immunogenicity.

Effects of highly concentrated SFN provided as BSE in T2D patients

Fig. 1. Construction of human liver seed grafts.

Fig. 4 Spatial mapping of the distribution and intensity of industrial fishing catch. Spatial mapping of the distribution and intensity of industrial fishing.

Fig. 4 Single-particle contact angle measurements.

Fig. 1 Closed-loop artificial pancreas systems.

Fig. 3 Performance of the generative model G, with and without stack-augmented memory. Performance of the generative model G, with and without stack-augmented.

Fig. 6 Representative 3D-printed models of image-based data.

Fig. 2 Comparison between the different reflective metasurface proposals when θi = 0° and θr = 70°. Comparison between the different reflective metasurface.

Fig. 5 Cytosolic delivery of toxic proteins.

Fig. 1 B2 RNA directly inhibits transcription.

Fig. 4 Gallium increases P. aeruginosa sensitivity to peroxides.

Fig. 2 Daily TNC pickups and drop-offs for an average Wednesday in fall 2016 (1). Daily TNC pickups and drop-offs for an average Wednesday in fall 2016.

Fig. 8 Immune correlates of protection.

Fig. 6 Schematic illustration of the decreased conformational stability in the N92I mutant and its activation mechanism. Schematic illustration of the.

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Fig. 4. A potential common pathogenic pathway for ALS/FTD. A potential common pathogenic pathway for ALS/FTD. ALS/FTD-associated RNA binding proteins have a PrLD, RRM, and NLS. These mutant RNA binding proteins become mislocalized from the nucleus to the cytoplasm due to disruption in nucleocytoplasmic trafficking caused by, for example, C9orf72 repeat expansions, pathological aggregation of proteins, or mutations in the NLS (A). This loss of function mediated by nuclear depletion may be involved in RNA dysregulation that results in neurodegeneration (B). The mislocalized RNA binding proteins assemble as cytoplasmic RNA granules (membraneless organelles formed by liquid-liquid phase separation) mediated by PrLDs (C), and the local concentration of proteins increases. Mutations in PrLDs lead to the formation of toxic protein aggregates and accelerate the formation of pathological inclusions (D). Meanwhile, the protein quality control system contributes by removing aberrant RNA granules and pathological inclusions. However, mutations in regulators of autophagy and the proteasome, as well as proteins containing dipeptide repeats, can disrupt the protein quality control system (E), leading to increased accumulation of RNA granules and pathological inclusions. In a toxic gain of function, the aberrant RNA granules and pathological inclusions (with a core composition of RNA binding proteins) trap RNAs and cause RNA dysregulation (F), leading to neuronal degeneration in ALS/FTD. Pathological protein aggregates may be transmitted from neuron to neuron in a “prion-like” manner (G). Complex interactions among these processes lead to the development of ALS/FTD. Daisuke Ito et al., Sci Transl Med 2017;9:eaah5436 Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works