James O. Menzoian, M. D. , Christian C. Haudenschild, M. D. , Jane L

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Presentation transcript:

Correction of enhanced endothelial permeability by cessation of cholesterol feeding James O. Menzoian, M.D., Christian C. Haudenschild, M.D., Jane L. Shipman, M.S., Cynthia J. Nickerson, B.S., Robin M. Fuller, B.S., Aram V. Chobanian, M.D. Journal of Vascular Surgery Volume 5, Issue 2, Pages 336-341 (February 1987) DOI: 10.1016/0741-5214(87)90142-X Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 1 Diagram of perfusion system of rabbit common carotid artery. A = jugular venous catheter for blood sampling; B = perfusate influx line; C = efflux line; D = perfusate reservoir; E = gas humidifier; F = peristaltic pump; and G = gas tank (95% oxygen, and 5% carbondioxide). (From Chobanian et al. Effects of endothelial denudation and cholesterol feeding on in vivo transport of albumin, glucose and water across rabbit carotid artery. Circ Res 1983;53:807.) Journal of Vascular Surgery 1987 5, 336-341DOI: (10.1016/0741-5214(87)90142-X) Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 2 Plasma cholesterol and carotid artery cholesterol content in chow-fed animals, cholesterol-fed animals, and “regression” animals. Journal of Vascular Surgery 1987 5, 336-341DOI: (10.1016/0741-5214(87)90142-X) Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 3 Appearance of 125I radioactivity in jugular venous blood after perfusion of common carotid artery with 125I-labeled albumin in chow-fed control animals, cholesterol-fed animals (12 to 15 weeks), and animals cholesterol-fed for 12 to 15 weeks with change to standard rabbit chow for 22 to 24 weeks. Values represent mean standard error for seven to nine animals at each time point. Journal of Vascular Surgery 1987 5, 336-341DOI: (10.1016/0741-5214(87)90142-X) Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions