Comparison of the Processing of the PEXEL Motif in P

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Comparison of the Processing of the PEXEL Motif in P Comparison of the Processing of the PEXEL Motif in P. falciparum and the RxLR Motif of AVR3a in P. infestans. Comparison of the Processing of the PEXEL Motif in P. falciparum and the RxLR Motif of AVR3a in P. infestans. The processing of AVR3a is strikingly similar to the stepwise modification observed for the PEXEL effectors from P. falciparum. However, the PEXEL motif (RxLxE/D/Q) is partially retained, while the RxLR motif is cleaved off completely, although both are acetylated (Ac). The corresponding RxLR-modifying enzymes remain to be investigated. NAT, N-terminal acetyltransferase; PEP, signal peptide peptidase; PMV, plasmepsin V; PTEX, Plasmodium translocon of exported proteins; SP, signal peptide. Stephan Wawra et al. Plant Cell 2017;29:1184-1195 ©2017 by American Society of Plant Biologists