Combination effect of AdTOP-PUMA and chemotherapeutic agents in colon cancer cells. Combination effect of AdTOP-PUMA and chemotherapeutic agents in colon.

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Combination effect of AdTOP-PUMA and chemotherapeutic agents in colon cancer cells. Combination effect of AdTOP-PUMA and chemotherapeutic agents in colon cancer cells. Cells were infected with the different viruses (5 MOI) and treated with various anticancer agents [paclitaxel, doxorubicin, and 5-florouracil (5-FU)]. One hundred percent indicates the viability of cells treated with PBS, without any agent or viral vector. Cell viability was determined 48 h after treatment with the various agents. Columns, mean of two quadruplicate assays; bars, SD. **, P < 0.01, significantly different from the AdTOP-PUMA (virus alone). Hadas Dvory-Sobol et al. Mol Cancer Ther 2006;5:2861-2871 ©2006 by American Association for Cancer Research