Temporal analysis of clonal evolution in typical FL and matched TFL samples. Temporal analysis of clonal evolution in typical FL and matched TFL samples.

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Temporal analysis of clonal evolution in typical FL and matched TFL samples. Temporal analysis of clonal evolution in typical FL and matched TFL samples. (A) Shown are cancer cell fractions of mutation clusters, plotted against time point (FL, TFL). The FL time point is shown on the x-axis, and the TFL time point on the y-axis. The emerging TFL-associated mutations can either not be detected, or are present at very low abundance in the preceding FL (<1%). (B) Time-sweep plot showing evolution over time of FL clones (in blue colors) and the emergence of TFL clones (in red and orange). Time is shown on the x-axis, clonal abundance on the y-axis. The transformed genotype is typically not readily detected in the initial FL biopsy, although it can be present in other anatomical sites, based on the data by Scherer et al.58 Adapted from Kridel et al24 in accordance with the Creative Commons Attribution (CC BY) license. Robert Kridel et al. Blood 2017;130:258-266 ©2017 by American Society of Hematology