(A) Erythropoietin response for all subjects, plotted by numerator and denominator of the measure. (A) Erythropoietin response for all subjects, plotted.

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(A) Erythropoietin response for all subjects, plotted by numerator and denominator of the measure. (A) Erythropoietin response for all subjects, plotted by numerator and denominator of the measure. Subjects were characterized by value of the erythropoietin response measure, which was categorized into quartiles (1st (○) 2nd (▪) 3rd (▴) and 4th (♦)). For each subject, the quartile of erythropoietin response was plotted by the increase in Epoetin alfa dose at randomization (denominator of the response measure) on the horizontal axis, and hematocrit response (numerator of the response measure, which was the hematocrit slope derived from a simple linear regression of study week on hematocrit) on the vertical axis. (B) Erythropoietin response as a function of prestudy (baseline) Epoetin alfa dose. Erythropoietin response values (•) on the vertical axis are shown plotted against baseline Epoetin alfa dose (×1000 U/wk) on the horizontal axis. A histogram showing the number of subjects at each level of baseline dose is shown in the background. Ryan D. Kilpatrick et al. CJASN 2008;3:1077-1083 ©2008 by American Society of Nephrology