Levocetirizine better protects than desloratadine in a nasal provocation with allergen Cédric Deruaz, MD, Annette Leimgruber, MD, Monika Berney, Estelle.

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Nasal challenge with allergen leads to maxillary sinus inflammation

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Levocetirizine better protects than desloratadine in a nasal provocation with allergen Cédric Deruaz, MD, Annette Leimgruber, MD, Monika Berney, Estelle Pradervand, François Spertini, MD Journal of Allergy and Clinical Immunology Volume 113, Issue 4, Pages 669-676 (April 2004) DOI: 10.1016/j.jaci.2004.01.773

Fig 1 Cumulative number of patients reaching the global threshold according to the dose level of grass pollen allergen. Inset, Difference (Δ) in allergen dose level necessary to reach the threshold for each of the 24 patients between levocetirizine and desloratadine (in favor of levocetirizine, >0; in favor of desloratadine, <0). Plain vertical line, Mean Δ allergen dose level. Journal of Allergy and Clinical Immunology 2004 113, 669-676DOI: (10.1016/j.jaci.2004.01.773)

Fig 2 Cumulative number of patients reaching the threshold according to the dose level of grass pollen allergen (X axis) for sneezes (A), secretions (B), PNIF (C), and MCA (D). In Fig 2, C and D, 24H corresponds to the 24-hour time point after the NPT. Insets, results are expressed as described in Fig 1. Journal of Allergy and Clinical Immunology 2004 113, 669-676DOI: (10.1016/j.jaci.2004.01.773)

Fig 3 Concentration of albumin (A) and tryptase (B) in nasal lavage fluid at baseline (sample 1), after the dose of 33,000 SQs of allergen (sample 2), and 24 hours after the NPT (sample 3). Data are expressed as means±SDs. ∗Levocetirizine versus placebo, P<.05. Journal of Allergy and Clinical Immunology 2004 113, 669-676DOI: (10.1016/j.jaci.2004.01.773)

Fig 4 Concentration of the late-phase inflammatory mediators IL-4 (A), IL-5 (B), IL-8 (C), and eotaxin (D) in nasal lavage fluid at baseline (sample 1), after the dose of 33,000 SQs of allergen (sample 2), and 24 hours after the NPT (sample 3). Data are expressed as means±SDs. Journal of Allergy and Clinical Immunology 2004 113, 669-676DOI: (10.1016/j.jaci.2004.01.773)

Fig 5 Eosinophil count (A) and ECP concentration (B) in nasal lavage fluid at baseline (sample 1), after the dose of 33,000 SQs of allergen (sample 2), and 24 hours after the NPT (sample 3). Data are expressed as means±SDs. Journal of Allergy and Clinical Immunology 2004 113, 669-676DOI: (10.1016/j.jaci.2004.01.773)