Effect of low-dose human atrial natriuretic peptide on postoperative atrial fibrillation in patients undergoing pulmonary resection for lung cancer: A.

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Presentation transcript:

Effect of low-dose human atrial natriuretic peptide on postoperative atrial fibrillation in patients undergoing pulmonary resection for lung cancer: A double-blind, placebo- controlled study Takashi Nojiri, MD, Kazuhiro Yamamoto, MD, FACC, Hajime Maeda, MD, Yukiyasu Takeuchi, MD, Yasunobu Funakoshi, MD, Masayoshi Inoue, MD, Meinoshin Okumura, MD The Journal of Thoracic and Cardiovascular Surgery Volume 143, Issue 2, Pages 488-494 (February 2012) DOI: 10.1016/j.jtcvs.2011.09.003 Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Summary of patients screened, giving consent, randomly allocated, and included in the study. hANP, Human atrial natriuretic peptide. The Journal of Thoracic and Cardiovascular Surgery 2012 143, 488-494DOI: (10.1016/j.jtcvs.2011.09.003) Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Daily distribution of postoperative atrial fibrillation in the placebo and human atrial natriuretic peptide (hANP) groups. D, Postoperative day. The Journal of Thoracic and Cardiovascular Surgery 2012 143, 488-494DOI: (10.1016/j.jtcvs.2011.09.003) Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Changes from preoperative baseline (Preop.) in perioperative parameters by postoperative day (D) and at 1 postoperative month (M). Each point with bars shows the mean ± SD. A, Changes in perioperative systolic blood pressure, diastolic blood pressure, heart rate, and urinary volume. There were no statistical differences between the placebo and human atrial natriuretic peptide (hANP) groups. B, Changes in plasma concentrations of atrial natriuretic peptide (ANP) in patients undergoing elective pulmonary resection for lung cancer who received an infusion of human atrial natriuretic peptide (hANP) or a placebo for 3 days. Double asterisk indicates P < .001. C, Changes in white blood cell counts (WBC) and C-reactive protein levels (CRP) in patients undergoing elective pulmonary resection for lung cancer who received an infusion of human atrial natriuretic peptide (hANP) or a placebo for 3 days. Asterisk indicates P < .05; double asterisk indicates P < .001. The Journal of Thoracic and Cardiovascular Surgery 2012 143, 488-494DOI: (10.1016/j.jtcvs.2011.09.003) Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions