AEA and URB597 reduce MCP-2, IL-6, and IL-8 levels in poly-(I:C)–stimulated HaCaT cells after 6 hours. AEA and URB597 reduce MCP-2, IL-6, and IL-8 levels.

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AEA and URB597 reduce MCP-2, IL-6, and IL-8 levels in poly-(I:C)–stimulated HaCaT cells after 6 hours. AEA and URB597 reduce MCP-2, IL-6, and IL-8 levels in poly-(I:C)–stimulated HaCaT cells after 6 hours. Enzyme-linked immunosorbent assay for MCP-2 (A) and Bio-Plex Pro assay for IL-6 (B) and IL-8 (C) release in the supernatants of poly-(I:C)–stimulated HaCaT cells (100 μg/ml, 6 hours, 37°C) in the presence of vehicle or CBD (20 μM), AEA (10 μM), or URB597 (10 μM). Data represent the mean ± S.E.M. of three independent experiments performed in triplicate. §§§P < 0.001 vs. vehicle; *P < 0.05; **P < 0.01; ***P < 0.001 vs. poly-(I:C). Assay range for MCP-2, 0.8–200 pg/ml; for IL-6, 37.68 pg/ml; and for IL-8, 42.15 pg/ml. Stefania Petrosino et al. J Pharmacol Exp Ther 2018;365:652-663 Copyright © 2018 by The American Society for Pharmacology and Experimental Therapeutics