Fighting MDR G-Negative Infections

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Presentation transcript:

Fighting MDR G-Negative Infections

What Is So Special About MDR GNB?

Resistance of CRE to Carbapenems

Classification and Characteristics of Major Carbapenemases in Enterobacteriaceae

Prevalence of Invasive CRE Infections Among Adult Patients in US Hospitals

Carbapenemase-Producing Enterobacteriaceae in the United States

Rise and Fall of KPC-Producing K Pneumoniae in New York City

Invasive K Pneumoniae Isolates With Resistance to Carbapenems, 2016

Prevalence of Carbapenem-Resistant K Pneumoniae in Different Provinces in China

Increasing Resistance of CRE K Pneumoniae in China

Reasons for the Increasing Prevalence of CRKP in China

CRE: Importance of Early and Effective Antibiotic Therapy

CRE Treatment and Assessment of Risk

Empiric Selection of Antibiotic Therapy

Selection of Empiric Therapy For Hospital-Acquired Infections

Importance of Local Epidemiology

Empirical Antibiotic Treatment Algorithm for HAP/VAP

Prediction Scores Studies for Certain ESKAPE Pathogens

CRE Infection: Combination Therapeutic Strategies

Treatment of CRE Infection in China: Challenges

KPC-2: Predominant Carbapenemase for CRKP in China

Treatment of CRE Infections in China

Ceftazidime-Avibactam: Clinical Considerations in Serious G-Negative Infections

Ceftazidime-Avibactam Treatment: Impact on Mortality

Meropenem-Vaborbactam: Clinical Considerations in Serious G-Negative Infections

TANGO II: Meropenem-Vaborbactam vs BAT in Patients With CR-Enterobacteriaceae Infections

Plazomicin: Clinical Considerations in Serious G-negative Infections

Plazomicin for Infections Caused by CRE: Results of the CARE Study

Eravacycline: Clinical Considerations in Serious G-Negative Infections

IGNITE 3: Eravacycline vs Ertapenem In cUTI

New Antibiotics in Development for the Treatment of CRE Infection

Features of a Successful Antibiotic Stewardship Program to Impact CRE

Program Summary

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Abbreviations (cont)