Mendelian randomization analysis demonstrates that low vitamin D is unlikely causative for pediatric asthma Erik B. Hysinger, MD, Jeffrey D. Roizen,

Slides:

Advertisements

Similar presentations

Early exposure to cow's milk protein is protective against IgE-mediated cow's milk protein allergy Yitzhak Katz, MD, Nelly Rajuan, MSc, Michael R. Goldberg,

Advertisements

Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.

Endoplasmic reticulum stress influences bronchial asthma pathogenesis by modulating nuclear factor κB activation So Ri Kim, MD, PhD, Dong Im Kim, MS, Mi.

David B. Price, FRCGP, Miguel Román-Rodríguez, MD, R

Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD

What drives prescription patterns in pediatric asthma management?

Association of physical activity, asthma, and allergies: A cohort of farming and nonfarming children Bettina Bringolf-Isler, MD, PhD, Eva Graf, MD, Marco.

Sangshin Park, DVM, MPH, PhD, Eun-Hee Lee, PhD, Younglim Kho, PhD

Susan L. Limb, MD, Kathryn C. Brown, MD, Robert A. Wood, MD, Robert A

Allergen immunotherapy: A practice parameter third update

Risk of an asthma exacerbation after bariatric surgery in adults

Interaction between IL13 genotype and environmental factors in the risk for allergic rhinitis in Korean children Woo Kyung Kim, MD, PhD, Ji-Won Kwon,

Alexandra Kazaks, MA, RD, Janet Y. Uriu-Adams, PhD, Judith S

Päivi M. Salo, PhD, Samuel J

Mendelian randomization analysis demonstrates that low vitamin D is unlikely causative for pediatric asthma Erik B. Hysinger, MD, Jeffrey D. Roizen,

Kyoung-Bok Min, MD, PhD, Jin-Young Min, PhD

Vitamin D Insufficiency and Asthma in a US Nationwide Study

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD

Ann-Marie M. Schoos, MD, PhD, Jacob D

Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study John M. Brehm, MD, MPH, Brooke Schuemann, BS,

Is 9 more than 2 also in allergic airway inflammation?

Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD

Rising prevalence of asthma is sex-specific in a US farming population

Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

Vitamin D levels and food and environmental allergies in the United States: Results from the National Health and Nutrition Examination Survey

Elina Jerschow, MD, MSc, Robert Y. Lin, MD, MSc, Moira M

Peter M. Wolfgram, MD, David B. Allen, MD

William J. Calhoun, MD, Tmirah Haselkorn, PhD, Dave P

Age-dependent effect of ambient ozone on emergency asthma hospitalizations in Hong Kong Yuanrong Dai, MD, Hong Qiu, PhD, Shengzhi Sun, PhD, Yang Yang,

Jewlya Lynn, PhD, Sophie Oppenheimer, MS, MPH, Lorena Zimmer, MA

Jon Genuneit, MD, MSc Journal of Allergy and Clinical Immunology

Debra J. Palmer, PhD, Thomas R. Sullivan, BMa&CompSc(Hons), Michael S

High eosinophil count: A potential biomarker for assessing successful omalizumab treatment effects William Busse, MD, Sheldon Spector, MD, Karin Rosén,

Berta Almoguera, PhD, Lyam Vazquez, MD, Frank Mentch, PhD, Michael E

Interaction between IL13 genotype and environmental factors in the risk for allergic rhinitis in Korean children Woo Kyung Kim, MD, PhD, Ji-Won Kwon,

Time for a paradigm shift in asthma treatment: From relieving bronchospasm to controlling systemic inflammation Leif Bjermer, MD Journal of Allergy.

Reduced risk of peanut sensitization following exposure through breast-feeding and early peanut introduction Tracy J. Pitt, MD, Allan B. Becker, MD,

Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management Scott H. Sicherer, MD, Hugh A. Sampson, MD Journal.

Nicola A. Hanania, MB BS, MS, Bradley E. Chipps, MD, Noelle M

Michael Schatz, MD, MS, Robert S

A cluster-randomized trial shows telephone peer coaching for parents reduces children's asthma morbidity Jane M. Garbutt, MB, ChB, Yan Yan, MD, PhD,

Claus Bachert, MD, PhD, Cezmi A. Akdis, MD

Rachel Enriquez, RN, PhD, Marie R. Griffin, MD, MPH, Kecia N

H. William Kelly, PharmD Journal of Allergy and Clinical Immunology

Autophagy: Nobel Prize 2016 and allergy and asthma research

Higher incidence of pediatric anaphylaxis in northern areas of the United States William J. Sheehan, MD, Dionne Graham, PhD, Lin Ma, MS, Sachin Baxi,

Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment

Diagnosis and management of early asthma in preschool-aged children

Päivi M. Salo, PhD, Samuel J

Geographic variability in childhood asthma prevalence in Chicago

Mary F. Linehan, PhD, Timothy L. Frank, MD, Michelle L

Alexandra Kazaks, MA, RD, Janet Y. Uriu-Adams, PhD, Judith S

Corinne A. Keet, MD, MS, Wayne G. Shreffler, MD, PhD, Roger D

Michael B. Fessler, MD, Mark W

What can urban/rural differences in food allergy prevalence tell us about the drivers of food allergy? Katrina J. Allen, MBBS, BMedSc, FRACP, FAAAI,

Day-care attendance, position in sibship, and early childhood wheezing: A population- based birth cohort study Nicolaos C. Nicolaou, MD, MPhil, Angela.

Association of physical activity, asthma, and allergies: A cohort of farming and nonfarming children Bettina Bringolf-Isler, MD, PhD, Eva Graf, MD, Marco.

Serum levels of Clara cell secretory protein, asthma, and lung function in the adult general population Marta Rava, PhD, Lluisa Tares, Iris Lavi, PhD,

Päivi M. Salo, PhD, Samuel J. Arbes, DDS, MPH, PhD, Patrick W

Macrolide antibiotics and asthma treatment

Frederikke K. Lomholt, BMSc, Sune F. Nielsen, PhD, Børge G

Asthma: The past, future, environment, and costs

Personal and parental nativity as risk factors for food sensitization

17q12-21 variants interact with smoke exposure as a risk factor for pediatric asthma but are equally associated with early-onset versus late-onset asthma.

Probiotic supplementation for the first 6 months of life fails to reduce the risk of atopic dermatitis and increases the risk of allergen sensitization.

The GILL study: Glycerin-induced local reactions in immunotherapy

Advances in pediatric asthma in 2007

Natural history of cow’s milk allergy

Primary prevention of asthma and allergy

Mepolizumab efficacy in patients with severe eosinophilic asthma receiving different controller therapies Frank C. Albers, MD, PhD, Robert G. Price,

Presentation transcript:

Mendelian randomization analysis demonstrates that low vitamin D is unlikely causative for pediatric asthma Erik B. Hysinger, MD, Jeffrey D. Roizen, MD, PhD, Frank D. Mentch, PhD, Lyam Vazquez, MD, John J. Connolly, PhD, Jonathan P. Bradfield, BS, Berta Almoguera, PhD, Patrick M. Sleiman, PhD, Julian L. Allen, MD, Michael A. Levine, MD, Hakon Hakonarson, MD, PhD Journal of Allergy and Clinical Immunology Volume 138, Issue 6, Pages 1747-1749.e4 (December 2016) DOI: 10.1016/j.jaci.2016.06.056 Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 A, Multivariate logistic regression model stratified by race comparing the odd ratio (OR) of asthma cases. B, Multivariate logistic regression model stratified by race comparing the OR of severe asthma exacerbations. Multivariate Poisson regression with robust variance stratified by race comparing the incidence rate ratio (IRR) of severe asthma exacerbations for cases with at least 1 severe exacerbation. OR/IRR is for a 10-ng/mL change in serum 25(OH)D concentration. All models are adjusted for age, sex, body mass index Z score, and month. Error bars indicate the 95% CI. Journal of Allergy and Clinical Immunology 2016 138, 1747-1749.e4DOI: (10.1016/j.jaci.2016.06.056) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Center for Applied Genomics study cohorts. Journal of Allergy and Clinical Immunology 2016 138, 1747-1749.e4DOI: (10.1016/j.jaci.2016.06.056) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Algorithm for the identification of asthma and asthma severity. LABA, Long-acting beta-agonist; LAMA, long-acting muscarinic antagonists; LTA, leukotriene antagonists. Journal of Allergy and Clinical Immunology 2016 138, 1747-1749.e4DOI: (10.1016/j.jaci.2016.06.056) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions