Increased levels of branching on serum glycoproteins from patients with HCC. A, focus on larger branched glycans from 4 representative cirrhotics, and.

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Increased levels of branching on serum glycoproteins from patients with HCC. A, focus on larger branched glycans from 4 representative cirrhotics, and 4 representative HCC samples highlighting specific changes in glycosylation observed in HCC. The A4G4 peak... Increased levels of branching on serum glycoproteins from patients with HCC. A, focus on larger branched glycans from 4 representative cirrhotics, and 4 representative HCC samples highlighting specific changes in glycosylation observed in HCC. The A4G4 peak is indicated with an asterisk. As in Fig. 2, sequential exoglycosidase digestion was used to identify N-linked glycan. B, scatter plot of the A4G4 glycan from 9 HCC and 8 cirrhotic patients showing the level of the A4G4 glycan in all patients. The solid line indicates the median level and the P value is indicated. Anand Mehta et al. Cancer Epidemiol Biomarkers Prev 2012;21:925-933 ©2012 by American Association for Cancer Research