Lecture Order 1) Receptor Trafficking Scaffolding Proteins at the PSD

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Lecture Order 1) Receptor Trafficking Scaffolding Proteins at the PSD NS1 Spring 2010 Lecture Order 1) Receptor Trafficking Scaffolding Proteins at the PSD Signaling at the PSD

Trends Neurosci. 25:578, 2002

J. Neurosci. 19:6298, 1999

TINS 30:407, 2007

Control of NMDA surface expression through ER retention signal

Tubulin -> microtubules Microfilaments -> actin <----Dynamic polymers <----Stable, only in neurons Neurofilaments -> NF-H, -M, -L Nature Reviews Neurscience 10:319, 2009

Nature Reviews Neurscience 10:319, 2009

Nature Reveiws MolCelBio 10:682, 2009

Science 279:519, 1998

cargo

minus-end directed motor plus-end directed motor

plus-end directed motor: axoneme travels toward stable tail (-) Axoneme Assay plus-end directed motor: axoneme travels toward stable tail (-) minus-end directed motor: axoneme travels toward unstable head (+) Science 288:1796, 2000 Nature 347:780, 1990

http://mc11.mcri.ac.uk/wrongtrousers.html http://mc11.mcri.ac.uk/wrongtrousers.html

http://www.scripps.edu/milligan/

Microtubule Motility Assay (plus directed motor) YFP-KIF17

J. Neurosci. 23:131, 2003 http://www.pnas.org/cgi/content/full/222371099/DC1/1

Nature Neurosci. 3:415, 2000

Role of endocytosis of ion channels in regulating synaptic efficacy Science 285:215, 1999

Nature Rev. Neurosci. 1:161, 2000

TINS 31:559, 2008

AMPA receptors and LTP/LTD

Nature Rev. Neurosci. 2:315, 315

Neuron 36:435, 2002