Figure 2. Performance of penalized likelihood for the estimation of the variance covariance matrix and comparison with ... Figure 2. Performance of penalized.

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Figure 2. Performance of penalized likelihood for the estimation of the variance covariance matrix and comparison with ... Figure 2. Performance of penalized likelihood for the estimation of the variance covariance matrix and comparison with other approaches. Quadratic loss between the simulated and estimated traits evolutionary variance-covariance matrix R obtained with the various (restricted) penalized likelihood approaches, the (restricted) pairwise composite likelihood approach, and the (restricted) maximum likelihood. Boxplots represent the median, first and 3rd quartile and range of Q loss values obtained over 1000 simulated data sets. Left panels ($p =$ 5) illustrate results with $p $< $n$ ($n =$ 32), and right panels ($p =$ 50) illustrate results with $p$ > $n$. Results with other $p$-values and unrestricted likelihoods are presented in Supplementary Figs. S7–S10 available on Dryad. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) 2018. Published by Oxford University Press, on behalf of the Society of Systematic Biologists. All rights reserved. For permissions, please email: journals.permissions@oup.comThis article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Syst Biol, Volume 68, Issue 1, 19 June 2018, Pages 93–116, https://doi.org/10.1093/sysbio/syy045 The content of this slide may be subject to copyright: please see the slide notes for details.

Figure 1. Performance of penalized likelihood for the estimation of model parameters and comparison with other ... Figure 1. Performance of penalized likelihood for the estimation of model parameters and comparison with other approaches. Estimates of the parameters of the OU, EB, and Pagel’s $\lambda $ models obtained with the various (restricted) penalized likelihood approaches, the (restricted) pairwise composite likelihood approach, and the (restricted) maximum likelihood. Boxplots represent the median, first and 3rd quartile and range of estimates obtained over 1000 simulated data sets. The red line represents simulated parameter values. Left panels ($p =$ 5) illustrate results with $p$ < $n$ ($n =$ 32), and right panels ($p =$ 50) illustrate results with $p$ > $n$. Results with other $p$-values and unrestricted likelihoods are presented in Supplementary Figs. S1–S6 available on Dryad. For $p$ > $n$, the approximated LOOCV approaches are not reliable (and thus not shown), and the maximum likelihood approach is not applicable. For each trait model, we report results for only four of the six simulated parameters for presentation purposes. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) 2018. Published by Oxford University Press, on behalf of the Society of Systematic Biologists. All rights reserved. For permissions, please email: journals.permissions@oup.comThis article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Syst Biol, Volume 68, Issue 1, 19 June 2018, Pages 93–116, https://doi.org/10.1093/sysbio/syy045 The content of this slide may be subject to copyright: please see the slide notes for details.

Figure 3. Performance of penalized likelihood for model selection and comparison with maximum likelihood. Model ... Figure 3. Performance of penalized likelihood for model selection and comparison with maximum likelihood. Model support, measured as the proportion of simulated data sets (over 1000) for which the generating model has the lowest GIC score, represented as a function of the model parameters and for $p$ ranging from smaller to larger than $n$ ($n =$ 32) ($p =$ 2, 5, 10, 25, 31, 50), with: (a–c) the restricted likelihood with archetypal ridge penalization, and (d–f) the restricted maximum likelihood approach. With penalized likelihood, the ability to recover the generating model increases with increasing dimensions, while with maximum likelihood it decreases as $p$ approaches $n$. Results with the unrestricted likelihood and other types of penalizations are presented in Supplementary Figs. S15–S17 available on Dryad. Note that the OU with $\alpha =$ 0, EB with $r =$ 0 and Pagel’s model with $\lambda =$ 1 are equivalent to BM, such that the % model support for these parameter values represent the false recovery rate. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) 2018. Published by Oxford University Press, on behalf of the Society of Systematic Biologists. All rights reserved. For permissions, please email: journals.permissions@oup.comThis article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Syst Biol, Volume 68, Issue 1, 19 June 2018, Pages 93–116, https://doi.org/10.1093/sysbio/syy045 The content of this slide may be subject to copyright: please see the slide notes for details.

Figure 4. New-World monkeys brain evolution Figure 4. New-World monkeys brain evolution. a) Brain endocast (of Pithecia irrorata) showing the position of the ... Figure 4. New-World monkeys brain evolution. a) Brain endocast (of Pithecia irrorata) showing the position of the anatomical landmarks (red), and surface (blue) and curve (green) semi-landmarks that were taken on each species (see Aristide et al. 2016). b) Maximum clade credibility tree showing the phylogenetic relationships for the 48 platyrrhine species considered in this study (see Aristide et al. 2015). Number on nodes indicates the location of reconstructions in d). c) Patterns of evolutionary integration and modularity in brain shape as represented by the first two principal component (PC) axes of the estimated evolutionary covariance matrix. Red colored areas represent regions changing concertedly along each PC axis. d) New world monkey ancestral brain shape reconstruction, and reconstructed evolutionary trajectories for two selected species. Colors depict the amount of change between a given state and the previous one, in terms of expansion (orange) or contraction (cyan) with respect to the center of the surface. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) 2018. Published by Oxford University Press, on behalf of the Society of Systematic Biologists. All rights reserved. For permissions, please email: journals.permissions@oup.comThis article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Syst Biol, Volume 68, Issue 1, 19 June 2018, Pages 93–116, https://doi.org/10.1093/sysbio/syy045 The content of this slide may be subject to copyright: please see the slide notes for details.