PD-L1 expression by melanocytes is observed in geographic association with TILs but does not depend on BRAF V600E. PD-L1 expression by melanocytes is observed.

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PD-L1 expression by melanocytes is observed in geographic association with TILs but does not depend on BRAF V600E. PD-L1 expression by melanocytes is observed in geographic association with TILs but does not depend on BRAF V600E. A, BRAF V600E melanoma metastatic to the lung with a “moderate” grade of immune infiltrates (yellow arrows) on H&E stain, immediately adjacent to melanocytes showing membranous PD-L1 expression by IHC. B, BRAF V600E melanoma metastatic to lymph node with no significant immune infiltrate and no PD-L1 expression by IHC. Melanin pigment is present in the cytoplasm. Original magnification, ×200 (all panels). Nemanja Rodić et al. Cancer Immunol Res 2015;3:110-115 ©2015 by American Association for Cancer Research