Development of SCLCs in B5 (AJ × Trp53F2-10/F2-10;Rb1F19/F19) mice.

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Development of SCLCs in B5 (AJ × Trp53F2-10/F2-10;Rb1F19/F19) mice. Development of SCLCs in B5 (AJ × Trp53F2-10/F2-10;Rb1F19/F19) mice. A, gross and histopathologic appearance of mSCLCs. a, gross appearance of mouse SCLC (black arrow). b, multiple dysplastic lesions (arrows) stained with H&E from a mouse 21 wk after intratracheal Adeno-Cre (×40). c, dysplastic lesion stained with H&E from a mouse 21 wk after intratracheal Adeno-Cre (×400). d, H&E stain of mSCLC from mouse 36 wk after intratracheal Adeno-Cre (×400). B, immunohistochemical staining on lung mSCLCs in B5 (AJ × Trp53F2-10/F2-10;Rb1F19/F19) mice with markers of neuroendocrine and epithelial differentiation. a, anti–chromogranin A antibody; b, anti–neuron-specific enolase antibody; c, anti–pro-surfactant protein-C antibody; d, anti-CC 10 antibody. Yian Wang et al. Cancer Prev Res 2009;2:1059-1064 ©2009 by American Association for Cancer Research