Effects of Androgen Deprivation Therapy on Pain Perception, Quality of Life, and Depression in Men With Prostate Cancer Thiago Gagliano-Jucá, MD, PhD,

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Presentation transcript:

Effects of Androgen Deprivation Therapy on Pain Perception, Quality of Life, and Depression in Men With Prostate Cancer Thiago Gagliano-Jucá, MD, PhD, Thomas G. Travison, PhD, Paul L. Nguyen, MD, Philip W. Kantoff, MD, Mary-Ellen Taplin, MD, Adam S. Kibel, MD, Robert Manley, BA, Kathleen Hally, BA, Richelle Bearup, MPH, Yusnie M. Beleva, BS, Grace Huang, MD, Robert R. Edwards, PhD, Shehzad Basaria, MD Journal of Pain and Symptom Management Volume 55, Issue 2, Pages 307-317.e1 (February 2018) DOI: 10.1016/j.jpainsymman.2017.09.017 Copyright © 2017 American Academy of Hospice and Palliative Medicine Terms and Conditions

Fig. 1 Changes in serum total testosterone levels in both groups. Data are displayed as means; error bars are 95% CI. ADT = androgen deprivation therapy. Journal of Pain and Symptom Management 2018 55, 307-317.e1DOI: (10.1016/j.jpainsymman.2017.09.017) Copyright © 2017 American Academy of Hospice and Palliative Medicine Terms and Conditions

Fig. 2 Changes in a) total BPI, b) BPI severity, and c) BPI interference scores during the study. Data are displayed as means; error bars are 95% CI. BPI = Brief Pain Inventory Questionnaire. ADT = androgen deprivation therapy. Journal of Pain and Symptom Management 2018 55, 307-317.e1DOI: (10.1016/j.jpainsymman.2017.09.017) Copyright © 2017 American Academy of Hospice and Palliative Medicine Terms and Conditions

Fig. 3 Changes in a) initial rating of pain, b) prolonged pressure pain at 30 seconds, c) prolonged pressure pain at 60 seconds, d) mechanical pain temporal summation, e) pain score with the first stimulus, f) pain score with the 10th stimulus, g) mechanical pain temporal summation in the distraction trial, h) pain score with the first stimulus in the distraction trial, i) pain score with the 10th stimulus in the distraction trial; j) cold pain tolerance, and k) conditioned pain modulation index in each group. Data are displayed as means; error bars are 95% CI. ADT = androgen deprivation therapy. Journal of Pain and Symptom Management 2018 55, 307-317.e1DOI: (10.1016/j.jpainsymman.2017.09.017) Copyright © 2017 American Academy of Hospice and Palliative Medicine Terms and Conditions

Fig. 4 Changes in a) composite scores of pain catastrophizing, b) helplessness, c) magnification, and d) rumination subdomain scores in each group. Data are displayed as means; error bars are 95% CI. ADT = androgen deprivation therapy; PCS = Pain Catastrophizing Scale. Journal of Pain and Symptom Management 2018 55, 307-317.e1DOI: (10.1016/j.jpainsymman.2017.09.017) Copyright © 2017 American Academy of Hospice and Palliative Medicine Terms and Conditions

Fig. 5 Changes in C-reactive protein concentrations in each group during the course of the study. Data are displayed as means; error bars are 95% CI. ADT = androgen deprivation therapy. Journal of Pain and Symptom Management 2018 55, 307-317.e1DOI: (10.1016/j.jpainsymman.2017.09.017) Copyright © 2017 American Academy of Hospice and Palliative Medicine Terms and Conditions

Fig. 6 Changes in a) depression scores on PHQ-9 questionnaire, b) physical functioning domain on SF-36 questionnaire, c) physical role limitations domain on SF-36, d) emotional well-being on SF-36 in each group, e) emotional role limitations on SF-36, and f) energy ratings on the SF-36. Data are displayed as means; error bars are 95% CI. ADT = androgen deprivation therapy; PHQ-9 = Patient Health Questionnaire; SF-36 = 36-Item Short-Form. Journal of Pain and Symptom Management 2018 55, 307-317.e1DOI: (10.1016/j.jpainsymman.2017.09.017) Copyright © 2017 American Academy of Hospice and Palliative Medicine Terms and Conditions

Fig. 7 Changes in a) STAI-state and b) STAI-trait scores in each group. Data are displayed as means; error bars are 95% CI. ADT = androgen deprivation therapy. Journal of Pain and Symptom Management 2018 55, 307-317.e1DOI: (10.1016/j.jpainsymman.2017.09.017) Copyright © 2017 American Academy of Hospice and Palliative Medicine Terms and Conditions

Supplementary Fig. 1 Changes in a) cold pain at 20 seconds, b) cold pain at 30 seconds after withdrawal of the hand, c) maximum cold pain, d) pressure at pain ratings between 35 and 45 KPa, e) average pressure generating maximum tolerable pain in the thumb, f) average pressure generating maximum tolerable pain in the trapezius, g) prolonged pressure pain in the leg at 90 seconds, h) prolonged pressure pain in the leg at 120 seconds, i) prolonged pressure pain in the leg 15 seconds after cuff was deflated, j) general health score on SF-36, k) pain score on SF-36, and l) social functioning score on SF-36. Data are displayed as means; error bars are 95% CI. ADT = androgen deprivation therapy; SF-36 = 36-Item Short Form. Journal of Pain and Symptom Management 2018 55, 307-317.e1DOI: (10.1016/j.jpainsymman.2017.09.017) Copyright © 2017 American Academy of Hospice and Palliative Medicine Terms and Conditions