Using Notches to Track Mammary Epithelial Cell Homeostasis

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Presentation transcript:

Using Notches to Track Mammary Epithelial Cell Homeostasis Gertraud W. Robinson Cell Stem Cell Volume 3, Issue 4, Pages 359-360 (October 2008) DOI: 10.1016/j.stem.2008.09.014 Copyright © 2008 Elsevier Inc. Terms and Conditions

Figure 1 Notch Regulates Cell Fate in Mammary Epithelium (A) Stem cells give rise to stem cells and multipotent progenitors, which then develop along either the luminal or myoepithelial (basal) lineage. Notch signals appear to be involved in signaling within and between the different cell types. (B) Reduction of Notch signals in stem cells promotes generation of stem cells and preferential differentiation toward the myoepithelial cell fate. (C) Directing constitutive Notch activation to stem cells or progenitor cells results in increased stem cell activity and transformation of cells in the luminal lineage. Cell Stem Cell 2008 3, 359-360DOI: (10.1016/j.stem.2008.09.014) Copyright © 2008 Elsevier Inc. Terms and Conditions