Landscape of the TME in gastric cancer and characteristics of TME subtypes. Landscape of the TME in gastric cancer and characteristics of TME subtypes.

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Landscape of the TME in gastric cancer and characteristics of TME subtypes. Landscape of the TME in gastric cancer and characteristics of TME subtypes. A, Cellular interaction of the TME cell types. Cell cluster A, blue; cell cluster B, red; cell cluster C, brown; cell cluster D, orange. The size of each cell represents survival impact of each TME cell type, calculation used the formula log10 (log-rank test P values indicated). Favorable factors for overall survival are indicated in green, and risk factors indicated in black. The lines connecting TME cells represent cellular interactions. The thickness of the line represents the strength of correlation estimated by Spearman correlation analysis. Positive correlation is indicated in red and negative correlation in blue. B, Kaplan–Meier curves for overall survival (OS) of 1,524 gastric cancer patients from seven gastric cancer cohorts (GSE15459, GSE29272, GSE34942, GSE57303, ACRG/GSE62254, GSE84437, and TCGA-STAD) with the TME infiltration classes. The numbers of patients in TMEcluster-A, -B, and -C phenotypes are n = 458, n = 625, and n = 441, respectively. Log-rank test shows overall P < 0.001. C, Unsupervised clustering of TME cells for 299 patients in the ACRG cohort. Immuno-group (immunophenotype from a previous study; ref. 7), survival status, ACRG subtype, MSI status, histologic subtype, gastric cancer grade, and TME cluster group are shown as patient annotations. D, Kaplan–Meier curves for OS of 299 patients in the ACRG cohort showing the association between TME infiltration patterns and OS (log-rank test, P < 0.001). Dongqiang Zeng et al. Cancer Immunol Res 2019;7:737-750 ©2019 by American Association for Cancer Research