OGD treatment increased tonic current through an oxidative reaction.

Slides:

Advertisements

Similar presentations

Cerebrovascular endothelial cells are protected from ischemic injury by STAT3 C.M. Davis and N.J. Alkayed Department of Anesthesiology and Perioperative.

Advertisements

The reading is 7.38 mm. The reading is 7.72 mm.

PI 3-kinase inhibition has no effect on ANG II induced extracellular recognition kinase (ERK) 1/2 activation. PI 3-kinase inhibition has no effect on ANG.

Lipid hydroperoxide levels (μM) in hepatic tissue lyaste after 1 and 5 h of reperfusion after 60 min of ischemia. Lipid hydroperoxide levels (μM) in hepatic.

SIRT3 in Calorie Restriction: Can You Hear Me Now?

الفعل ورد الفعل ♠ ♠ ♠ مجلس أبوظبي للتعليم منطقة العين التعليمية

Average for the DV ratio (DVR) images for [11C]raclopride for the controls (n = 20) and the alcoholics (n = 20) at the level of striatum after placebo.

Supplementary Figure S5, Lecoeur et al.

Mitochondrial cardiolipin plays a key role in macrophage inflammasome activation in response to apoptotic mitochondria. Mitochondrial cardiolipin plays.

Endogenous phosphorylation of Atp1a3 is regulated by phosphatases.

Whole-cell patch-clamp analysis of NAc cells.

Vitamin D3 levels alter amphetamine-related behaviors in mice.

Guillaume Bossis, Frauke Melchior Molecular Cell

Fig. 6 DMF inhibits NF-κB translocation upon infection.

An antagonistic relationship between myosin II and dynein controls bulk growth cone advance. An antagonistic relationship between myosin II and dynein.

Stomatal aperture. Stomatal aperture. A, Stomata of the different lines with (+) and without (-) ABA treatment as photographed during the experiments.

Correlations between indices of oxidative status and individual condition. Correlations between indices of oxidative status and individual condition. Lines.

Effect of γ-secretase inhibition on the vulnerability of primary neurons to OGD. (A) Experimental design. Effect of γ-secretase inhibition on the vulnerability.

Number of patients who would have benefitted from addition of ACE inhibitor (ACEi), beta blockers (BB) or optimal therapy (one or both of ACEi and BB)

Expression of candidate neuronal IEGs in the brain of cycloheximide pretreated crickets 30 min after PTX injection. Expression of candidate neuronal IEGs.

Depolarization-induced postsynaptic NT secretion depends on Ca2+ influx. Depolarization-induced postsynaptic NT secretion depends on Ca2+ influx. Hippocampal.

Unaltered presynaptic transmitter secretion during pharmacological treatments. Unaltered presynaptic transmitter secretion during pharmacological treatments.

Caspase activation occurs after AIF translocation and nuclear condensation. Caspase activation occurs after AIF translocation and nuclear condensation.

ATF4 overexpression preserves parkin protein levels after treatment with dopaminergic neuronal toxins. ATF4 overexpression preserves parkin protein levels.

SiRNA directed at Ngn1 inhibited differentiation of inner ear stem cells to β-III tubulin-positive cells. a, Inner ear stem cells treated with siRNA to.

The effect of benzolamide on NH4+-induced pHi transients in cultured mouse hippocampal neurons. The effect of benzolamide on NH4+-induced pHi transients.

Interaction between reboxetine and ADRA2B genotype influences post-treatment symptoms of irritability, anxiety, and dizziness. Interaction between reboxetine.

Effect of IBMP and PKG on cAMP levels

MSK1 is necessary for BDNF-dependent CREB phosphorylation in area CA1.

HIF-1 is required for IGF-1-induced VEGF mRNA expression and protein secretion. HIF-1 is required for IGF-1-induced VEGF mRNA expression and protein secretion.

Fluorescence staining of F-actin in cultured astrocytes isolated from wild-type, MMP-2 null, and MMP-9 null mice using Texas Red-conjugated phalloidin.

Spinal application of naloxone did not change population responses of superficial and deep WDR neurons to graded intracutaneous electrical stimuli in wild-type.

Blockade of the Nogo receptor NgR1 enhances LTP in the rat primary motor cortex. Blockade of the Nogo receptor NgR1 enhances LTP in the rat primary motor.

Top row, Example high-resolution deconvolved optical z-stack of a dendritic segment used for spine analysis with NeuronStudio software. Top row, Example.

NCS-Rapgef2-dependent ERK activation in mouse NAc following D1 dopamine receptor agonist SKF and psychostimulants D-amphetamine or cocaine administration.

MCM and ACM treatment of acutely isolated MNs results in differential caspase activation and utilization. MCM and ACM treatment of acutely isolated MNs.

Tactile allodynia with activation of dorsal horn neuron in atopy model mice. Tactile allodynia with activation of dorsal horn neuron in atopy model mice.

Activation of LHAGal neurons reduces compulsive burying.

Oligomeric Aβ42 treatment induces expression of Ras and Cyclin D1 and activation of ERK in primary rat cortical neurons. Oligomeric Aβ42 treatment induces.

Effect of PPARγ agonist on Aβ phagocytosis in primary microglia.

An ERK-signaling process underlies HFS-induced LTP at TA-CA1 synapses.

Glycogen content of rat optic nerves after glucose deprivation and pharmacological manipulation. Glycogen content of rat optic nerves after glucose deprivation.

Motoneuron numbers (mean ± SEM) in 48 hr control cultures (open bar) and in cultures treated with either 100 nm thrombin (hatched bars), 1 μm YVAD-CHO,

A, B, Startle magnitude and PPI after treatment with CNO

Paraquat induces selective loss of subsets of dopaminergic neurons.

GABA and corticosterone selectively affect the activity of NE- and KCl-responsive precursor cells. GABA and corticosterone selectively affect the activity.

Inhibition of forskolin-induced cAMP accumulation in microglia by group III mGlu receptor agonists and receptor coupling to pertussis toxin-sensitive G-proteins.

PTEN inhibition unmasks the antihyperalgesic efficacy of the δR agonist SNC80. PTEN inhibition unmasks the antihyperalgesic efficacy of the δR agonist.

HFD increased the number of ERα-expressing cells.

HDAC inhibitor induces RAG transcription in sensory neurons.

Associations between the differences in BDNF or TrkB mRNA expression and in GAD67 mRNA expression across subject pairs. Associations between the differences.

At 1 month, control and les rats were fed AL or fasted every other day for IF. Representative images of 1 μm sections, with electron micrograph insets.

Electron micrograph of large IC neuron with dense VGLUT2+ axosomatic endings. a, VGLUT2+ terminals contain an electron-dense reaction product and surround.

A, Cleavage of the caspase fluorogenic substrate zDEVD-afc (12

SSC LTP in narrow-field vertical neurons is induced by SO stimulation at 20 Hz for 20 s. sSC LTP in narrow-field vertical neurons is induced by SO stimulation.

ROS generation at reoxygenation is attributable to NADPH oxidase and is calcium dependent. ROS generation at reoxygenation is attributable to NADPH oxidase.

Brain ischemic tolerance model using mouse MCAO

Effects of receptor antagonists, Ca2+ channel blocker, Ca2+depletion, and protein kinase inhibitors on CREB phosphorylation in cultured hippocampal neurons.

Pulse treatment of actinomycin D shows a biphasic effect on LTAM

Parkin message and protein are differentially affected by dopaminergic neuronal toxins. Parkin message and protein are differentially affected by dopaminergic.

Effects of CNO on spontaneous locomotion and amphetamine-induced hyperlocomotion. Effects of CNO on spontaneous locomotion and amphetamine-induced hyperlocomotion.

Target-specific DSI at TRN synapses.

SLC30A10 protects DAergic neurons from neurodegeneration induced by Mn exposure. SLC30A10 protects DAergic neurons from neurodegeneration induced by Mn.

A, Representative voltage-clamp recordings from a CRF1+ neuron during superfusion of GBZ (100 μm), followed by PTX (100 μm, top trace) and during superfusion.

ET-1 effect on neuronal viability and blood flow.

Effects of rapamycin, cycloheximide, and an MAP kinase inhibitor (U0126) on BDNF-mediated increase in Arc and CaMKII in acute hippocampal slices. Effects.

Whole mounts (A-D; ×20), and H&E sections (E-H, ×100) of the mammary gland. Whole mounts (A-D; ×20), and H&E sections (E-H, ×100) of the mammary gland.

A, B, 5-HT1A immunoreactivity in hippocampal dendrites (CA3) of saline-treated (A) and fluoxetine-treated (B) rats. A, B, 5-HT1A immunoreactivity in hippocampal.

Partial restoration of impaired LTP in hippocampal slices from 12-month-old NCAM−/− mice through inhibition of GluN2B-containing receptor signaling. Partial.

The effect of roscovitine on Ca2+-dependent glutamate release from synaptosomes prepared from rat brains in response to membrane depolarization with 1.

Presentation transcript:

OGD treatment increased tonic current through an oxidative reaction. OGD treatment increased tonic current through an oxidative reaction. A, Reperfusion after OGD increased tonic current; n = 9, **p = 0.006, Student's paired t test. B, C, The increase in tonic current by reperfusion was abolished and a decrease after reperfusion was observed for neurons treated with the antioxidant GSH (1 mm; B) or pretreated for 30 min with NADPH oxidase inhibitor DPI (10 μm; C). Student's paired t test; n = 7, *p = 0.03 for B; n = 7, ***p < 0.001 for C. Antonello Penna et al. J. Neurosci. 2014;34:10624-10634 ©2014 by Society for Neuroscience