Amppos tumors are a distinct tumor subpopulation.

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Amppos tumors are a distinct tumor subpopulation. Amppos tumors are a distinct tumor subpopulation. A, representative IHC photomicrographs for BrdUrd, vWF, and F4/80. Scale bar, 50 μm (BrdUrd) and 100 μm (vWF and F4/80). B, IHCs were quantified using automated image analysis (n ≥ 7; *, P < 0.01; **, P < 0.05). C, qPCR analysis of tumor-associated (protumorigenic) and classically activated (antitumorigenic) macrophage markers. Each dot represents a different tumor. The cross line signifies geometric mean (n.s., not significant; **, P < 0.01; ***, P < 0.001). D, immunofluorescent stain for MRC1 on Ampneg and Amppos tumors. Scale bar, 40 μm. E, quantification of MRC1 immunofluorescence. Bars represent geometric mean; **, P < 0.01. Elad Horwitz et al. Cancer Discovery 2014;4:730-743 ©2014 by American Association for Cancer Research