A recurrent gain in the VEGFA locus identifying a molecularly distinct tumor subpopulation. A recurrent gain in the VEGFA locus identifying a molecularly.

Slides:

Advertisements

Similar presentations

Fig. 8. Recurrent copy number amplification of BRD4 gene was observed across common cancers. Recurrent copy number amplification of BRD4 gene was observed.

Advertisements

Rearrangements of Gene A and Gene B

Volume 147, Issue 1, (September 2011)

Fig. 4. Primary human metastatic melanomas contain CCL21-expressing LECs, and expression of VEGFC positively correlates with hallmarks of tumor inflammation.

Vegfa is overexpressed by E11

Binding of 53BP1 on uncapped telomeres.

TIE2hi/VEGFAhi TEMs are present in the TMEM

Copy-number alterations in an archival breast cancer sample.

Recombination between Palindromes P5 and P1 on the Human Y Chromosome Causes Massive Deletions and Spermatogenic Failure Sjoerd Repping, Helen Skaletsky,

Post-transcriptional deregulation of hnRNPH3 in sciatic nerve and neural cell bodies by loss of Ranbp2. Post-transcriptional deregulation of hnRNPH3 in.

XL184 effects on RIP-Tag2 tumor invasion and epithelial/mesenchymal markers. XL184 effects on RIP-Tag2 tumor invasion and epithelial/mesenchymal markers.

G34 induces a transcriptional program linked to forebrain development and self-renewal. G34 induces a transcriptional program linked to forebrain development.

Candidates with a PVM localization.

Volume 7, Issue 9, Pages (September 2014)

PD-1 expression on HCC-infiltrating B cells and its clinical significance. PD-1 expression on HCC-infiltrating B cells and its clinical significance. A–H,

A role for galectin-3 in promoting lung colonization in ST6GalNAc2-silenced cells. A role for galectin-3 in promoting lung colonization in ST6GalNAc2-silenced.

Histology and genomic copy number alterations in TRAMP tumors.

Volume 22, Issue 5, Pages (May 2014)

Role of Chromosome 3q Amplification in Lung Cancer

KIF1Bβ promotes DHX9 nuclear localization.

BDNF expression in the cerebellum and brain stem region.

Subcellular localization of UUKV, HRTV, and SFTSV NSs

Inhibition of VEGFA or macrophage-specific ablation of Vegfa from TIE2hi/VEGFAhi TMEM macrophages reduces vascular permeability and tumor cell intravasation.

Identification and characterization of a novel KRAS rearrangement in metastatic prostate cancer. Identification and characterization of a novel KRAS rearrangement.

HER-2/neu mRNA detection by gene expression profiling

Existence of a nuclear NFATc1–STAT3 complex in pancreatic cancer.

Localization of PBANKA_ and PBANKA_ during blood and liver stage development. Localization of PBANKA_ and PBANKA_ during blood.

Identification of candidate genes within the 1q32 locus.

Cell system for following and quantifying single-gene transcription in fixed and living cells. Cell system for following and quantifying single-gene transcription.

Direct visualization by RNA FISH of TLR7 escape from X inactivation in B cells from women. Direct visualization by RNA FISH of TLR7 escape from X inactivation.

TSA causes premature chromatid sister separation.

Temporal dynamics of the primitive streak and mesoderm progenitors in β-catenin-activated hES cells. Temporal dynamics of the primitive streak and mesoderm.

Fig. 2. Ex vivo inducible knockout of PDCD2 in ESCs results in loss of S phase entry and increased p53.(A) Growth curve of inducible knockout and WT ESCs.

Comparison ofMyc-induced zebrafish liver tumors with different stages of human HCC and seven mouse HCC models. Comparison ofMyc-induced zebrafish liver.

Lysine residues in the cytoplasmic region of TfR are involved in the MARCH8-induced downregulation of TfR. Lysine residues in the cytoplasmic region of.

Sequence variation of 16S rRNA gene primer-binding sites.

BEZ235 induces MAPK signaling in a FOXO3A-dependent manner.

FISH with pooled large-insert clones representing chromosome 17 early-replicating (green) and chromosome 5 late-replicating (red) loci to (A) human (schematics.

Ctip2 directly regulates Notch1 expression in differentiated cells.

CLIC1 promotes tumor cell spreading through effects on MLCK

EZH2 overexpression establishes a unique and conserved super-enhancer–associated transcriptional landscape. EZH2 overexpression establishes a unique and.

Integrated mRNA and microRNA expression and DNA methylation clusters.

Amppos tumors are a distinct tumor subpopulation.

A, unsupervised clustering of all BRCA1 (red), BRCA2 (blue), and sporadic (green) breast tumors of our collection using the regions reported as discriminative.

HCCs with overexpression of biliary/progenitor marker genes.

MET amplification is selected in KRAS wild-type colorectal cancer samples from patients who developed resistance to anti-EGFR treatment. MET amplification.

Binding and antiproliferative effects of ANG4043 and anti-HER2 mAbs on tumor cells. Binding and antiproliferative effects of ANG4043 and anti-HER2 mAbs.

CLIC1 is upregulated in invadopodia of fibrin-embedded tumor and endothelial cells. CLIC1 is upregulated in invadopodia of fibrin-embedded tumor and endothelial.

A macrophage-tumor cell cross-talk within Amppos tumors.

Dual-color FISH analysis of 16p13

Β-catenin knockout inhibits synovial sarcoma (SS) tumor growth in SYT–SSX2 transgenic mice. β-catenin knockout inhibits synovial sarcoma (SS) tumor growth.

Activation status of CD8+ T cells.

Purified Vpr induces double-strand breaks in vitro.

The activity of MRP1-EYFP is analogous to wild-type MRP1.

PI3Kγ promotes macrophage PDGF-BB expression to control PDAC fibrosis.

Maps of Structures of the Ruby Locus in the Different Citrus Species, Orange Accessions, and Hybrids.Thick green arrows, retrotransposon LTRs; thick gray.

Snail-induced multinucleation follows midbody persistence.

A, heatmap of copy number alterations determined by array CGH for a panel of 79 frozen NSCLC samples. A, heatmap of copy number alterations determined.

G34 H3K36me3 upregulates MYCN which is selectively targetable by kinases that destabilize the protein. G34 H3K36me3 upregulates MYCN which is selectively.

VEGF-A inhibition impedes proliferation in Amppos tumors.

EZH2-driven lung cancer as a molecularly distinct entity.

mRNA expression of PARP1 in SCLC cell lines and solid tumors.

Coculture with U937 cells enhances DNMT1 expression in gastric cancer cells. Coculture with U937 cells enhances DNMT1 expression in gastric cancer cells.

A, indicated model systems were cultured in media containing complete serum, harvested, and lysed; total protein was separated by SDS-PAGE, transferred.

AtSPO11-1–Dependent sRNAs Show Enrichment at Meiotic CO-Associated DNA Motifs. AtSPO11-1–Dependent sRNAs Show Enrichment at Meiotic CO-Associated DNA Motifs.

Integrated analysis of gene expression and copy number alterations.

Mutant TERT promoter displays active histone marks and distinct long-range interactions: A, cell lines that were used in the study with their origin and.

HER2 amplification in EGFRT790M–negative tumors with acquired resistance. HER2 amplification in EGFRT790M–negative tumors with acquired resistance. A,HER2.

Synthetic lethality of ROS1 inhibition in E-cadherin–deficient breast tumor cell lines. Synthetic lethality of ROS1 inhibition in E-cadherin–deficient.

Centrosome anomalies characterize colorectal cancer with rhabdoid phenotype. Centrosome anomalies characterize colorectal cancer with rhabdoid phenotype.

Presentation transcript:

A recurrent gain in the VEGFA locus identifying a molecularly distinct tumor subpopulation. A recurrent gain in the VEGFA locus identifying a molecularly distinct tumor subpopulation. A, representative photomicrographs of CISH using probes specific for the murine Chr17qB3. B, DNA qPCR analysis using primers specific for different loci on the qB3 arm of chromosome 17. Each vertical line represents a single Amppos tumor. The thin line represents nonamplified regions, and the thick line represents amplified regions. The list includes several of the residing genes (a full list is available as Supplementary Data). C, representative photomicrographs of FISH of human HCC using Chr6p12 probe (red) and chromosome 6 centromere probe (green). D, qPCR analysis of the mRNA levels of murine genes encoded on the amplified region. Each dot represents a different tumor. The cross line signifies geometric mean (n.s., not significant; **, P < 0.01; ***, P < 0.0001). E, qPCR and ELISA analyses of VEGF-A performed on extracts of wild-type (WT) livers, Ampneg, and AmpposMdr2−/− tumors in matching pairs show a correlation between the increase in mRNA and protein levels. F, confocal microscopy images of an Mdr2−/− Amppos tumor immunostained for E-cadherin and VEGF-A. Hoechst 33342 marks nuclei. Scale bar, 20 μm. Elad Horwitz et al. Cancer Discovery 2014;4:730-743 ©2014 by American Association for Cancer Research