LINC00092 binds with PFKFB2 to promote ovarian cancer metastasis.

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LINC00092 binds with PFKFB2 to promote ovarian cancer metastasis. LINC00092 binds with PFKFB2 to promote ovarian cancer metastasis. A, Relative mRNA levels of key glycolytic enzymes in control A2780s cell line and LINC00092-overexpressing (OE) A2780s cell line. B, Western blotting analysis of RNA pull-down assays from A2780s cellular extracts was performed. An Ab against the EZH2 protein was used as the negative control. C, Kaplan–Meier analysis of TCGA patients with ovarian carcinoma for the correlation between HK-1, PFKFB2, and LDHA protein expression and overall survival (n = 565). D, Immunohistochemical analysis of PFKFB2 in specimens of normal ovary, ovarian cancer without metastasis, and ovarian cancer with metastasis (normal group n = 10, ovarian cancer without metastasis group n = 15, ovarian cancer with metastasis group n = 20). E, The expression of PFKFB2 in ovarian surface epithelium (OSE), ovarian tumor, normal ovary, stroma and ovarian tumor stroma in CSIOVDB analysis. F, The expression of PFKFB2 in normal ovary and ovarian cancer in TCGA dataset. G, The expression of PFKFB2 in early-stage (FIGO stage I and II) ovarian cancer and advanced stage (FIGO stage IIII and IV) in Gilks cohort. *, P < 0.05; **, P < 0.01; ***, P < 0.001. Scale bar, 50 μm. Linjie Zhao et al. Cancer Res 2017;77:1369-1382 ©2017 by American Association for Cancer Research