The cGAS-STING Pathway for DNA Sensing

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The cGAS-STING Pathway for DNA Sensing T. Sam Xiao, Katherine A. Fitzgerald Molecular Cell Volume 51, Issue 2, Pages 135-139 (July 2013) DOI: 10.1016/j.molcel.2013.07.004 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 The cGAS-STING Pathway for DNA Sensing cGAS binds dsDNA using a “zinc thumb” structure and a positively charged surface. DNA association induces a structural switch that repositions the catalytic residues to bind the GTP and ATP substrates mediated by magnesium ions. The catalysis proceeds from a 2′-5′ GpA linkage to a 3′-5 ApG linkage and forms a cyclic dinucleotide 2′3′-cGAMP, which then binds and initiates large structural rearrangements in STING. The resulting STING-cGAMP complex may then promote TBK1 and IRF3 activation through its CTT. The zinc and magnesium ions that bind cGAS are colored cyan and green, respectively. The 2′3′-cGAMP is shown as spheres bound to STING. Molecular Cell 2013 51, 135-139DOI: (10.1016/j.molcel.2013.07.004) Copyright © 2013 Elsevier Inc. Terms and Conditions