CXCL14-positive CAFs induce overexpression of LINC00092 in ovarian cancer. CXCL14-positive CAFs induce overexpression of LINC00092 in ovarian cancer. A,

Slides:



Advertisements
Similar presentations
INCREASED EXPRESSION OF PROTEIN KINASE CK2  SUBUNIT IN HUMAN GASTRIC CARCINOMA Kai-Yuan Lin 1 and Yih-Huei Uen 1,2,3 1 Department of Medical Research,
Advertisements

KG-501 suppresses NSCLC/IL-1β CM–induced migration of HUVECs by regulating IL-1β–induced CXC chemokine gene expression in NSCLC cells. KG-501 suppresses.
IL-1β differentially regulates CXCL5 and CXCL8 protein secretion in NHTBE and NSCLC cells. IL-1β differentially regulates CXCL5 and CXCL8 protein secretion.
IL-1β stimulates CXCL5 and CXCL8 gene expression and protein secretion in A549 cells in a time- and dose-dependent manner. IL-1β stimulates CXCL5 and CXCL8.
Volume 71, Issue 2, Pages (February 2017)
Prognostic significance of DDB2 in ovarian cancer.
Kaplan–Meier curves for a, b) progression-free survival (PFS) and c, d) overall survival (OS) in a, c) large-cell neuroendocrine carcinoma patients and.
Volume 7, Issue 4, Pages (April 2005)
Learning More from Microarrays: Insights from Modules and Networks
Somatic promoters correlate with immunoediting signatures.
(A) Hierarchical clustering was performed to identify groups of patients with similar RNASeq expression of 20 genes associated with reduced survivability.
Treatment of human MCC tumors with intralesional IFNβ is associated with MHC-I upregulation. Treatment of human MCC tumors with intralesional IFNβ is associated.
B7-H4 expression correlates with MHC-I expression and improved prognosis in patients with breast cancer. B7-H4 expression correlates with MHC-I expression.
CHK1 downregulation upon ERG overexpression.
IL32 prompts cell activation and cancer-related pathways.
Microarray analysis of phospho-Twist1–responsive genes.
PD-1 expression on HCC-infiltrating B cells and its clinical significance. PD-1 expression on HCC-infiltrating B cells and its clinical significance. A–H,
Fig. 7 CSPG4-high GBMs show more microglia than CSPG4-low GBMs and express TNFα. CSPG4-high GBMs show more microglia than CSPG4-low GBMs and express TNFα.
AZA treatment induces a distinct gene-expression pattern in stromal cells. AZA treatment induces a distinct gene-expression pattern in stromal cells. (A-C)
Quantification of MHC-I, β2m, and T-cell subsets.
SIRT1 is downregulated in human gastric cancer (GC).
SW fraction induces S phase arrest and apoptosis.
Volume 2, Issue 3, Pages (March 2016)
ADCY5 is expressed in isolated human islets and affected by T2D risk alleles. ADCY5 is expressed in isolated human islets and affected by T2D risk alleles.
Distinct molecular and clinical correlates of H3F3A mutation subgroups
Correlation of RSPO expression to LGR5 expansion in gastric cancer.
Fig. 6 WPS imaging of different chemical components in living cells.
Peripheral CAF model. Peripheral CAF model. A, bright field (top) and fluorescence (bottom) micrographs of aggregates that contain RFP-tagged 344SQ cells.
Association between RB pathway alterations and poor prognosis in early-stage lung adenocarcinoma patients. Association between RB pathway alterations and.
PD-L1 expression correlates with T-cell markers and an IFN response signature in human melanomas. PD-L1 expression correlates with T-cell markers and an.
Protein expression profile in a dasatinib-resistant cell line.
MMP-1 functionally contributes to HEp3-hi/diss intravasation and metastasis. MMP-1 functionally contributes to HEp3-hi/diss intravasation and metastasis.
LINC00092 binds with PFKFB2 to promote ovarian cancer metastasis.
Heat map of genes for which CR significantly altered expression versus AL. Cluster analysis of genes significantly changed by the CR intervention compared.
Reduced BAI1 expression is associated with breast cancer patient survival. Reduced BAI1 expression is associated with breast cancer patient survival. A,
AXL is not expressed in human prostate tumors.
CD8, galectin-3, galectin-9, and the M1/M2 ratio are associated with a longer survival. CD8, galectin-3, galectin-9, and the M1/M2 ratio are associated.
IL-13Rα2 expression is associated to human colon cancer progression and poor survival of patients with colorectal cancer. IL-13Rα2 expression is associated.
Immune responses to 12MP and 6MHP.
EN1 expression in breast cancer and clinical outcome.
ALDH1A3 expression levels are inversely correlated with the survival of patients with resectable mass-forming and advanced cholangiocarcinoma, respectively.
Cocultivation of fibroblasts with epithelial cells (EP156T-luc).
Survival risk prediction analysis and application of the metastasis gene signature. Survival risk prediction analysis and application of the metastasis.
CREBBP loss-of-function results in gene expression repression signature. CREBBP loss-of-function results in gene expression repression signature. A–D,
Example inverse FF-OCT images (left column) and corresponding histology images (right column) of ovarian metastases. Example inverse FF-OCT images (left.
Reduced klotho expression in pancreatic cancer.
MYC–HOXB7–HER2 predicts clinical outcome in breast cancer patients treated with tamoxifen. MYC–HOXB7–HER2 predicts clinical outcome in breast cancer patients.
Expression of PCNA, K10, and K5 in skin lesions from Stat3+/−:HPV8 and Stat3+/+:HPV8 mice. Expression of PCNA, K10, and K5 in skin lesions from Stat3+/−:HPV8.
Exacerbation of genomic instability and radiosensitization upon RUNX3 or HMOX1 depletion in the presence of TGFβ. Exacerbation of genomic instability and.
Expression of HIF-1α and β-catenin in hypoxic HCC cell lines and HAL-treated xenografts. Expression of HIF-1α and β-catenin in hypoxic HCC cell lines and.
lncRNA HOXA11-AS is overexpressed in gastric cancer tissues.
Transfection efficiency and PicoGreen cell survival assays.
Patient stratification using survival risk prediction and BCLC staging
Regression analysis showing the positive correlation between number of months since the prior chemotherapy regimen (X axis) and the difference between.
Expression of chemokine receptors in A-498 cell line.
IL-1β expression is increased in MM cell lines by the co-culture with platelets in vitro. IL-1β expression is increased in MM cell lines by the co-culture.
MYC and LYN are coexpressed and have interdependent clinical outcomes.
Expression of TGFβ ligands in GBM
Immunohistochemical determination of TIM-3 expression in ccRCC.
Cell counts of immune infiltrate and expression of galectin-1 and galectin-3 in the short-, medium-, and long-term survival cohorts. Cell counts of immune.
Effect of SFN on the total activity and protein expression of HDACs in JB6 P+ cells. Effect of SFN on the total activity and protein expression of HDACs.
NUAK1 overexpression correlates with tumor progression, lymph node infiltrates, and reduced overall survival (OS) in human colorectal cancer. NUAK1 overexpression.
Highly metastatic PDAC cells have a unique gene signature, which is not preserved in metastases but predicts poor patient outcome. Highly metastatic PDAC.
SCLC initiated from pulmonary neuroendocrine cells metastasizes without upregulating NFIB. A and B, Mouse models of SCLC. Rb1flox/flox;Trp53flox/flox;p130flox/flox;R26mTmG.
Overexpression of SUFU and GLI1 in the poor clinical outcome subgroup was confirmed by real-time PCR along with its association with disease progression.
DYNLRB1, AIMP1, and NPIPA1 expression correlate with survival in neuroblastoma. DYNLRB1, AIMP1, and NPIPA1 expression correlate with survival in neuroblastoma.
The inverse correlation between PARP1 and PD-L1, PAR, and p-STAT3 expression in surgical specimens of ovarian cancer. The inverse correlation between PARP1.
Construction of TME signatures and functional annotation.
Characteristic gene expression patterns distinguish LCH cells from other immune cells present in LCH lesions. Characteristic gene expression patterns distinguish.
PD and efficacy of AZD4785 in a KRAS wild-type lung cancer PDX model
Presentation transcript:

CXCL14-positive CAFs induce overexpression of LINC00092 in ovarian cancer. CXCL14-positive CAFs induce overexpression of LINC00092 in ovarian cancer. A, Cluster maps of top upregulated or downregulated lncRNAs in A2780s ovarian cancer cell line treated with recombinant CXCL14 protein or control. Expression of lncRNAs upregulated in the CXCL14-treated group and the downregulated proteins are shown. B, Relative levels of LINC00092 in A2780s ovarian cancer cell line cultured in CAF-CM and NAF-CM, respectively. C, Relative levels of LINC00092 in A2780s ovarian cancer cell line cultured in CAF-CM and NAF-CM, respectively. D, Relative LINC00092 levels in specimens from normal ovary, ovarian cancer patients with metastasis, and ovarian cancer patients without metastasis. E, Correlation between relative LINC00092 level and stromal CXCL14 immunostaining scores in ovarian cancer patients with linear regression lines and Pearson correlation significance. F, Representative immunostaining graphs of stromal CXCL14 expression in LINC00092-high and LINC00092-low ovarian cancer specimens. We have stratified the ovarian cancer clinical samples into two categories, including LINC00092-high group and LINC00092-low group, based on median LINC00092 expression value as the cutoff. G, Kaplan–Meier analysis of ovarian cancer patients showing a significant correlation between LINC00092 expression and progression-free survival and overall survival in Mateescu's cohort (n = 107). *, P < 0.05; **, P < 0.01; ***, P < 0.001. Scale bar, 50 μm. Linjie Zhao et al. Cancer Res 2017;77:1369-1382 ©2017 by American Association for Cancer Research