Astrocyte number and morphologic status assessed by GFAP immunohistochemistry in E3FAD and E4FAD mice across dietary treatments. Astrocyte number and morphologic.

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Astrocyte number and morphologic status assessed by GFAP immunohistochemistry in E3FAD and E4FAD mice across dietary treatments. Astrocyte number and morphologic status assessed by GFAP immunohistochemistry in E3FAD and E4FAD mice across dietary treatments. A, Representative images of astrocyte morphology associated with resting and reactive phenotypes. Scale bar, 50 µm. B–E, Densities (cells/mm2) of GFAP-immunoreactive cells in E3FAD and E4FAD mice on control and Western diets were quantified in (B) entorhinal cortex, and hippocampal subregions (C) subiculum, (D) CA1, and (E) CA2/3. F–I, Percentages of all GFAP-immunoreactive cells scored as having reactive phenotype (type 2) were quantified in (F) entorhinal cortex, and hippocampal subregions (G) subiculum, (H) CA1, and (I) CA2/3. Data are presented as mean (±SEM) values; n = 7–11/group. E3FAD mice are shown as circles, E4FAD mice are shown as squares; control diet groups are indicated as open symbols, and Western diet groups as filled symbols. *, p < 0.05 relative to genotype-matched mice in control diet condition. #, p < 0.05 relative to E3FAD mice in same diet condition. V. Alexandra Moser, and Christian J. Pike eNeuro 2017;4:ENEURO.0077-17.2017 ©2017 by Society for Neuroscience