Fig. 1 The seven nasal CSTs and their respective bacterial densities shown in boxplots and composition shown in heatmap visualization and non-metric multidimensional.

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Fig. 1 The seven nasal CSTs and their respective bacterial densities shown in boxplots and composition shown in heatmap visualization and non-metric multidimensional scaling (nMDS) ordination plot. The seven nasal CSTs and their respective bacterial densities shown in boxplots and composition shown in heatmap visualization and non-metric multidimensional scaling (nMDS) ordination plot. (A) In the boxplots, the box of each boxplot denotes the IQR (Q2-Q3) and the corresponding median, whereas the whiskers signify the upper and lower 1.5 × IQR, and the open circles denote outliers beyond the whiskers. The difference in bacterial density was significantly greater across than within CSTs [analysis of variance (ANOVA), P < 0.001]. In particular, CST3 had significantly lower bacterial density than all other CSTs except CST4, and CST2 had significantly higher bacterial density than all other CSTs except CST6 (two-tailed Wilcoxon rank sum, P < 0.05) (A). (B) In the heatmap visualization, each participant’s nasal microbiota is represented in a single column, and proportional abundance of each nasal bacterial taxon is shown by row according to the color key to the left. The nasal microbiota is grouped by CSTs, as indicated by the CST color bar above. The S. aureus culture result of each participant is noted by the green/black color bar above. (C) In the nMDS ordination plot, each participant’s nasal microbiota (in proportional abundance) is represented by a single data point, and data points that are closer have a more similar composition than those that are farther apart. The centroids and 95% confidence ellipse for each CST are shown. Cindy M. Liu et al. Sci Adv 2015;1:e1400216 Copyright © 2015, The Authors