Association of HIV-1 replication fitness, as measured in a whole-virus parallel infection assay, with ability to control viremia after treatment interruption.

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Association of HIV-1 replication fitness, as measured in a whole-virus parallel infection assay, with ability to control viremia after treatment interruption. Association of HIV-1 replication fitness, as measured in a whole-virus parallel infection assay, with ability to control viremia after treatment interruption. The x axis indicates the slope of the change in culture p24 antigen between days 0 and 6 after infection; the y axis indicates the log10 of patient's viral load. Panels depict the correlation between HIV-1 replication fitness using this assay and preantiretroviral therapy (ART) viral load (a), post-structured treatment interruption (STI) viral load (b), and viral load change during STI (c). (Modified from reference 163 with permission.)‏ Carrie Dykes, and Lisa M. Demeter Clin. Microbiol. Rev. 2007; doi:10.1128/CMR.00017-07