SATB2-AS1 repressed Snail transcription depending on SATB2-mediated recruitment of HDAC1. SATB2-AS1 repressed Snail transcription depending on SATB2-mediated.

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SATB2-AS1 repressed Snail transcription depending on SATB2-mediated recruitment of HDAC1. SATB2-AS1 repressed Snail transcription depending on SATB2-mediated recruitment of HDAC1. A, GSEA showed the enrichment of metastasis signatures in colorectal carcinoma cells with SATB2 downregulation. B and C, Both SATB2-AS1 and SATB2 inhibited the expression of Snail on mRNA and protein levels. D, ChIP analysis of SATB2 occupancy on the Snail promoter. Immunoprecipitated DNA was compared with input and is shown as percentage. Data are represented as mean ± SD. E, Coimmunoprecipitation of endogenous HDAC1 with anti SATB2 antibodies (top) and endogenous SATB2 with anti-HDAC1 antibodies (bottom) in colorectal carcinoma cells. F, ChIP analysis of HDAC1 occupancy on the Snail gene. Significantly increased recruitment of HDAC1 to Snail promoter was observed upon SATB2-AS1 overexpression. G, Dual luciferase reporter assay was performed in colorectal carcinoma cells to verify the effect of SATB2 on Snail promoter activity. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ns, nonsignificant. Yi-Qing Wang et al. Cancer Res 2019;79:3542-3556 ©2019 by American Association for Cancer Research