Fig. 2 Suv420h dKO mice have improved metabolic parameters.

Slides:

Advertisements

Similar presentations

Fig. 5 Correlation of RNA expression and protein abundance.

Advertisements

Fig. 2 Transport properties of a BP transistor at low temperature.

Fig. 3 The electrical contact of direct-printed and reconfigured liquid metals. The electrical contact of direct-printed and reconfigured liquid metals.

Fig. 2 Global production, use, and fate of polymer resins, synthetic fibers, and additives (1950 to 2015; in million metric tons). Global production, use,

Vibrational spectra of medieval human bones (Leopoli-Cencelle, Italy)

Fig. 5 Thermal conductivity of n-type ZrCoBi-based half-Heuslers.

Fig. 1 Characterization of Suv420h dKO mice.

Fig. 1 Map of water stress and shale plays.

Fig. 1 Crystal and electronic structure of WTe2.

Fig. 1 Examples of experimental stimuli and behavioral performance.

Fig. 2 Some examples of weekly forecasts (the number of the forecasts are reported on Table 1). Some examples of weekly forecasts (the number of the forecasts.

Fig. 4 Resynthesized complex boronic acid derivatives based on different scaffolds on a millimole scale and corresponding yields. Resynthesized complex.

Fig. 6 Comparison of properties of water models.

Fig. 1 Mean and median RCR (Relative Citation Ratio) of Roadmap Epigenomics Program research articles for each year. Mean and median RCR (Relative Citation.

Fig. 2 Reference-fixing experiment, results.

Fig. 2 The glucose binding and charge-switch study.

Fig. 3 Glucose- and structure-dependent insulin release.

Fig. 2 TRXSS data. TRXSS data. TRXSS data covering delay times from 10 ns to 10 ms for wild-type DmCry (A), for the DmCry(H378A) mutant (B), and for XlPho.

Fig. 3 Rotation experiment, setup.

Fig. 1 Product lifetime distributions for the eight industrial use sectors plotted as log-normal probability distribution functions (PDF). Product lifetime.

Fig. 5 In vivo evaluation of F-insulin for treatment of type 1 diabetic minipig. In vivo evaluation of F-insulin for treatment of type 1 diabetic minipig.

Fig. 1 Reference-fixing experiment, setup.

Fig. 5 Transcriptional changes in dKO mice after HFD regimen.

Fig. 3 Gate voltage dependence of the areal iDMI and PMA.

Fig. 4 In vivo clinical trials.

Fig. 1 Distribution of total and fake news shares.

Fig. 2 2D QWs of different propagation lengths.

Fig. 5 Molecular dynamics simulations of Rac1.

Fig. 6 WPS imaging of different chemical components in living cells.

Fig. 4 DFT ωB97x/def2-TZVPP atomic charges on the sulfur atom of substituted thioaldehyde and AIMNet prediction with a different number of iterative passes.

Fig. 5 Simultaneous absence of caspase-3 and -7 is required for significant decrease of caspase-8 and -9 activation in intrinsic apoptosis. Simultaneous.

Fig. 3 ET dynamics on the control and treatment watersheds during the pretreatment and treatment periods. ET dynamics on the control and treatment watersheds.

Fig. 4 Fast transition of memory systems contributions over repeated rehearsal of new words in the second session. Fast transition of memory systems contributions.

Fig. 1 Histograms of the number of first messages received by men and women in each of our four cities. Histograms of the number of first messages received.

Fig. 5 Schematic phase diagrams of Ising spin systems and Mott transition systems. Schematic phase diagrams of Ising spin systems and Mott transition systems.

Fig. 3 Transcriptional changes in dKO mice.

Fig. 4 OER performance of ACoO3 (A = Ca, Sr) in alkaline solutions with different pH. OER performance of ACoO3 (A = Ca, Sr) in alkaline solutions with.

Fig. 1 Average contribution (million metric tons) of seafood-producing sectors, 2009–2014. Average contribution (million metric tons) of seafood-producing.

Fig. 4 The mechanical performances of thermally stable click-ionogels.

Fig. 2 Magnetic properties of FGT/Pt bilayer.

Fig. 2 Results of the learning and testing phases.

Fig. 2 Schematic drawings of Göbekli Tepe skulls.

Fig. 2 NH3, NOx, SO2, and NMVOC emission changes triggered by the JJJ clean air policy. NH3, NOx, SO2, and NMVOC emission changes triggered by the JJJ.

Fig. 1 Size fractions of MPPs in different fertilizers.

Fig. 4 Dox-CBD-SA treatment shows reduced toxicity.

Fig. 1 Global occurrences of hydraulic fracturing–induced seismicity and potential models. Global occurrences of hydraulic fracturing–induced seismicity.

Fig. 2 Top 10 countries, ecoregions, conservation hotspots, and KBAs with the largest area of restoration hotspots. Top 10 countries, ecoregions, conservation.

Fig. 6 PPAR-γ is a direct target of Suv420h.

Fig. 5 Global patterns in total fisheries catches from over more than 50 years as seen in three example stanzas. Global patterns in total fisheries catches.

Fig. 5 Comparison of the liquid products generated from photocatalytic CO2 reduction reactions (CO2RR) and CO reduction reactions (CORR) on two catalysts.

Schematic of the proposed brain-controlled assistive hearing device

Fig. 1 Location of the Jirzankal Cemetery.

Fig. 4 CO2 emission changes triggered by the JJJ clean air policy.

Fig. 2 Simulations of possible doping positions and band structures.

Fig. 4 Phase diagram showing significant order parameters ∣pk∣ versus T and wc. Phase diagram showing significant order parameters ∣pk∣ versus T and wc.

Fig. 2 Mean field results. Mean field results. (A) Solutions P(x) to Eq. 4 for a range of T and wc = (B) Modulus ∣pk∣ of order parameters versus.

Fig. 6 Stabilization of hippocampal signaling over sleep.

Fig. 3 Comparisons of NDVI trends over the globally vegetated areas from 1982 to Comparisons of NDVI trends over the globally vegetated areas from.

Fig. 6 IVIS Lumina scan of mice and of their organs after intravenous administration of fluorescent LENK-SQ-Am NPs or control fluorescent dye solution.

Fig. 1 Schematic depiction of a paradigm for rapid and guided discovery of materials through iterative combination of ML with HiTp experimentation. Schematic.

Fig. 4 Mapping of abundance of the most dominant bacterial and archaeal phyla across France. Mapping of abundance of the most dominant bacterial and archaeal.

Fig. 4 Spatial mapping of the distribution and intensity of industrial fishing catch. Spatial mapping of the distribution and intensity of industrial fishing.

Fig. 4 Single-particle contact angle measurements.

Fig. 3 Performance of the generative model G, with and without stack-augmented memory. Performance of the generative model G, with and without stack-augmented.

Fig. 4 Behavior of resistance peak near density nm = 5.

Fig. 2 Comparison between the different reflective metasurface proposals when θi = 0° and θr = 70°. Comparison between the different reflective metasurface.

Fig. 1 Doping schematics and optical properties.

Fig. 3 Calculated electronic structure of ZrCoBi.

Fig. 1 Attractive interaction between a doublon and a holon due to antiferromagnetic exchange interactions in half-filled 2D Mott insulators. Attractive.

Fig. 3 Evaluation of PTMAO immunogenicity.

Presentation transcript:

Fig. 2 Suv420h dKO mice have improved metabolic parameters. Suv420h dKO mice have improved metabolic parameters. (A) Basal glycemia measured in overnight-fasted control and dKO mice (n = 6 per genotype). Glucose levels were measured from the tail vein using a standard glucometer. (B) GTT performed in control and dKO mice after overnight fasting. The test was performed by intraperitoneally injecting d-glucose (2 g/kg). Blood glucose levels were measured at the indicated time points (5, 10, 15, 30, 45, 60, and 120 min after glucose administration) from the tail vein using a standard glucometer (n = 6 per genotype). a.u., arbitrary units. (C and D) Gene expression analysis of Suv420h1, Suv420h2, Ucp1, Pgc1a, and Dio2 mRNA by RT-qPCR performed in iBAT of mice with or without cold exposure (n = 6 per genotype). (E and F) Left: Basal core rectal temperature of control and dKO mice recorded at room temperature (RT) using a rectal probe (RET-3, ThermoWorks). Right: Rectal temperature in acute cold challenge (right) (n = 6 per genotype) measured hourly for 6 hours. Values are expressed as mean ± SEM; t test; *P < 0.05; **P < 0.01; ***P < 0.001. n.s., not significant. Simona Pedrotti et al. Sci Adv 2019;5:eaav1472 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).