Kaplan-Meier plot of overall survival from the time of first dose of intrathecal interleukin-2 (IT IL-2) for all patients (A, n=43) and based on the extent of extracranial disease (B). Kaplan-Meier plot of overall survival from the time of first dose of intrathecal interleukin-2 (IT IL-2) for all patients (A, n=43) and based on the extent of extracranial disease (B). Also, 12 patients had no extracranial disease at time of first IT IL-2 treatment, 20 patients had controlled disease and 11 patients had uncontrolled disease. LMD, leptomeningeal disease. Isabella C Glitza et al. ESMO Open 2018;3:e000283 Copyright © European Society for Medical Oncology. All rights reserved.