Fig. 4 Bcl11b regulates expression of key Treg cell genes while suppressing inflammatory and innate genes. Bcl11b regulates expression of key Treg cell.

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Fig. 5 Correlation of RNA expression and protein abundance.

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Fig. 4 Bcl11b regulates expression of key Treg cell genes while suppressing inflammatory and innate genes. Bcl11b regulates expression of key Treg cell genes while suppressing inflammatory and innate genes. (A) GSEA showing enrichment of Treg signature genes in WT Treg cells (n = 2) compared with Bcl11b KO Treg cells (n = 2). RNA-seq was conducted on Treg cells sorted from Bcl11b/Treg KO mosaic and WT female mice. NES, normalized enrichment score. (B) Graphs showing normalized read counts of key Treg genes from RNA-seq of Bcl11b KO and WT Treg cells (n = 2). (C) GSEA plots showing enrichment of inflammatory and allograft rejection pathways in Bcl11b KO Treg cells versus WT (n = 2). (D) Heatmap of normalized read counts of myeloid and NK cell program genes from RNA-seq of Bcl11b KO and WT Treg cells (n = 2). (E) Graphs showing normalized read counts of selected myeloid and NK cell genes (n = 2). (F) Distribution of fold changes of differentially expressed (DE) genes between Bcl11b KO and WT Treg cells at steady state and in EAE. FC, fold change. (G) Venn diagram of the proportion of unique and shared differentially expressed genes between Bcl11b KO and WT Treg cells at steady state and in EAE. (H) Scatter plot of RNA-seq log2 (fold change) of the Treg signature genes at steady state and in EAE. False discovery rate (FDR)–adjusted P values were calculated using the Benjamini-Hochberg method, with a significance cutoff of adjusted P < 0.05. Theodore T. Drashansky et al. Sci Adv 2019;5:eaaw0480 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).