K+ secretion in the distal nephron.

Slides:

Advertisements

Similar presentations

How it works….step by step: At rest, the inside of the neuron is slightly negative due to a higher concentration of positively charged sodium ions outside.

Advertisements

ELECTROLYTE DISASTERS JOSE-MARIE EL-AMM NEPHROLOGY DIVISION WSU/DMC/HUH AUGUST, 2006 POTASSIUM.

1 Lecture-5 Dr. Zahoor. Objectives – Tubular Secretion Define tubular secretion Role of tubular secretion in maintaining K + conc. Mechanisms of tubular.

The Physiology of the Loop of Henle. Structure The loop composes the pars recta of the proximal tubule (thick descending limb), the thin descending and.

Volume of Urine GFR ~ L/d Urine, ~ 0.5 – 15 L/d.

CONTROL OF EXTRACELLULAR FLUID VOLUME AND REGULATION OF RENAL NaCL EXCRETION.

The Physiology of the Distal Tubules and Collecting Ducts.

Blood Water Homeostasis (Osmoregulation)

Dr. Shaikh Mujeeb Ahmed Assistant Professor AlMaarefa College

Sodium-Potassium pumps The cell membrane as an electrical battery.

Answers to renal physiology problems worked in class Robert G. Carroll, Ph.D. Brody School of Medicine East Carolina University View presentation using.

Tubular Reabsorption and regulation of tubular reabsorption Tortora Ebaa M Alzayadneh, PhD.

Tubular reabsorption.

Potassium, Calcium, Phosphate & Magnesium Balance

Renal tubule transport mechanisms

TUBULAR REABSORPTION Part II

Biff F. Palmer, MD, Deborah J. Clegg, PhD Mayo Clinic Proceedings

Nat. Rev. Nephrol. doi: /nrneph

Na,K-ATPase displays distinct polarized localization in different tissues and developmental stages. Na,K-ATPase displays distinct polarized localization.

Volume 79, Issue 9, Pages (May 2011)

Life and death of the distal nephron: WNK4 and NCC as major players

Volume 75, Issue 1, Pages (January 2009)

Making sense of the sensor: Mysteries of the macula densa

On the measurement of the functional properties of the CFTR

Regional sodium handling, urine diuretic levels, and plasma aldosterone in groups with high or low loop diuretic–induced increase in FELi or FENa. Group.

Paolo Ferrari, M.D., Zygmunt Krozowski Kidney International

A trail of research on potassium

Renal and extrarenal regulation of potassium

What Color is it?.

Volume 71, Issue 5, Pages (March 2007)

Kamel S. Kamel, Martin Schreiber, Mitchell L. Halperin

REGULATION OF K+EXCRETION

Biff F. Palmer, MD American Journal of Kidney Diseases

Vasopressin in chronic kidney disease: an elephant in the room?

Regulation of renal tubular secretion of organic compounds

Volume 76, Issue 8, Pages (October 2009)

Volume 83, Issue 4, Pages (April 2013)

Disorders of the epithelial sodium channel: Insights into the regulation of extracellular volume and blood pressure Principal discussant: John B. Stokes

Transcellular movement of organic cations (OCs) and organic anions (OAs) in kidney proximal tubule epithelial cells. Transcellular movement of organic.

Mechanism of action of drugs commonly used to treat hyponatremia.

Need to quickly excrete K+? Turn off NCC

Two channels for one job

An Unusual Case of Metabolic Alkalosis: A Window Into the Pathophysiology and Diagnosis of This Common Acid-Base Disturbance F. John Gennari, MD, Sarah.

Hyperkalemia: An adaptive response in chronic renal insufficiency

Reemergence of the maxi K+ as a K+ secretory channel

S. Susan Hedayati, Essam F. Elsayed, Robert F. Reilly

Renal potassium channels: Function, regulation, and structure

A new regulator of the vacuolar H+-ATPase in the kidney

Volume 86, Issue 1, Pages (July 2014)

Resembles hyperkalemia

Volume 72, Issue 4, Pages (August 2007)

Model of proximal ammonia transport.

General considerations of proximal tubule transport.

Ammonia secretion by the collecting duct.

WNK kinases regulate sodium chloride and potassium transport by the aldosterone- sensitive distal nephron A.R. Subramanya, C.-L. Yang, J.A. McCormick,

Volume 70, Issue 1, Pages (July 2006)

Key apical membrane ion transporters and channels in various segments of the gastrointestinal tract. Key apical membrane ion transporters and channels.

Mechanism of diminished NaCl and Mg2+ reabsorption in EAST/SeSAME syndrome. Mechanism of diminished NaCl and Mg2+reabsorption in EAST/SeSAME syndrome.

Volume 74, Issue 11, Pages (December 2008)

Molecular biology of distal nephron sodium transport mechanisms

Cetuximab (C) is an EGF receptor (EGFR) antibody that causes renal magnesium wasting by competing with EGF for its receptor. Cetuximab (C) is an EGF receptor.

Regulation of Tubular Reabsorption

Intercalated cells in rat collecting duct.

Intercalated cells are involved in K+secretion in the collecting duct

SGLT-2 mediates glucose reabsorption in the kidney.

Model of major transport processes and regulatory mechanisms in type B intercalated cells. Model of major transport processes and regulatory mechanisms.

Model of regulatory pathways for the mineralocorticoid receptor (MR) in intercalated cells: hyperkalemia and volume depletion. Model of regulatory pathways.

Lithium transport pathways in proximal and distal tubule cells.

Under normal circumstances, delivery of Na+ to the distal nephron is inversely associated with serum aldosterone levels. Under normal circumstances, delivery.

Presentation transcript:

K+ secretion in the distal nephron. K+ secretion in the distal nephron. K+ is taken up into cells across the basolateral membrane via Na-K-ATPases (blue oval) and secreted into luminal fluid via apical ROMK channels (yellow cylinder). Sodium (Na+) reabsorption via ENaC (green cylinder) depolarizes the apical membrane potential and provides the driving force for K+ secretion (indicated by dotted line and plus sign). Thus, increased Na+ delivery (indicated by black line) would stimulate K+ secretion. Aldosterone increases sodium reabsorption via ENaC to stimulate K+ secretion (indicated by red line). Chou-Long Huang, and Elizabeth Kuo JASN 2007;18:2649-2652 ©2007 by American Society of Nephrology