Fig. 3 Transcriptional changes in dKO mice.

Slides:

Advertisements

Similar presentations

Fig. 5 Correlation of RNA expression and protein abundance.

Advertisements

Fig. 4 Altitudinal distributions of ice thickness change (m year−1) for the 650 glaciers. Altitudinal distributions of ice thickness change (m year−1)

Fig. 2 Global production, use, and fate of polymer resins, synthetic fibers, and additives (1950 to 2015; in million metric tons). Global production, use,

Vibrational spectra of medieval human bones (Leopoli-Cencelle, Italy)

Fig. 5 Thermal conductivity of n-type ZrCoBi-based half-Heuslers.

Fig. 1 Characterization of Suv420h dKO mice.

Fig. 1 Map of water stress and shale plays.

Fig. 1 Examples of experimental stimuli and behavioral performance.

Fig. 4 Resynthesized complex boronic acid derivatives based on different scaffolds on a millimole scale and corresponding yields. Resynthesized complex.

Fig. 2 IT1t prevents TLR7-mediated inflammation in pDCs.

Fig. 2 Reference-fixing experiment, results.

Fig. 1 Experimental apparatus used to train and test free-flying bees on their capacity to learn addition and subtraction. Experimental apparatus used.

Fig. 3 Rotation experiment, setup.

Fig. 1 Product lifetime distributions for the eight industrial use sectors plotted as log-normal probability distribution functions (PDF). Product lifetime.

Fig. 5 Transcriptional changes in dKO mice after HFD regimen.

Fig. 3 Gate voltage dependence of the areal iDMI and PMA.

Fig. 1 Distribution of total and fake news shares.

Fig. 3 Characteristics of UV and temperature sensors.

Fig. 2 Expressions of cll, abd-A, and Abd-B by qRT-PCR.

Fig. 2 2D QWs of different propagation lengths.

Electronic structure of the oligomer (n = 8) at the UB3LYP/6-31G

Fig. 4 EUV TG signal from Si.

Fig. 4 DFT ωB97x/def2-TZVPP atomic charges on the sulfur atom of substituted thioaldehyde and AIMNet prediction with a different number of iterative passes.

Fig. 4 Control analyses ensured that the relation between rotational acceleration and changes in FA does not depend on thresholds. Control analyses ensured.

Fig. 4 DEGs in the skin and the blood of P. leucopus with or without B

Fig. 1 A time-course RNA-seq analysis reveals prominent IRF8 expression in the spinal cord during the recovery phase after SCI. A time-course RNA-seq analysis.

Fig. 3 ET dynamics on the control and treatment watersheds during the pretreatment and treatment periods. ET dynamics on the control and treatment watersheds.

Fig. 5 n-HA regulates gene expressions related to tumor suppression, calcium homeostasis, and immune response. n-HA regulates gene expressions related.

Fig. 1 Histograms of the number of first messages received by men and women in each of our four cities. Histograms of the number of first messages received.

Fig. 5 Schematic phase diagrams of Ising spin systems and Mott transition systems. Schematic phase diagrams of Ising spin systems and Mott transition systems.

Fig. 2 Suv420h dKO mice have improved metabolic parameters.

Fig. 4 Bcl11b regulates expression of key Treg cell genes while suppressing inflammatory and innate genes. Bcl11b regulates expression of key Treg cell.

Fig. 4 OER performance of ACoO3 (A = Ca, Sr) in alkaline solutions with different pH. OER performance of ACoO3 (A = Ca, Sr) in alkaline solutions with.

Fig. 1 Average contribution (million metric tons) of seafood-producing sectors, 2009–2014. Average contribution (million metric tons) of seafood-producing.

Fig. 4 Visualization of complex loop motions by 1-μs MD trajectories.

Fig. 3 Production of protein and Fe(II) at the end of growth correlated with increasing concentrations of ferrihydrite in the media that contained 0.2.

Fig. 2 Schematic drawings of Göbekli Tepe skulls.

Fig. 4 SPICE simulation of stochasticity.

Fig. 2 NH3, NOx, SO2, and NMVOC emission changes triggered by the JJJ clean air policy. NH3, NOx, SO2, and NMVOC emission changes triggered by the JJJ.

Fig. 4 Differential histone modifications at promoters in various brain cell populations. Differential histone modifications at promoters in various brain.

Fig. 2 Top 10 countries, ecoregions, conservation hotspots, and KBAs with the largest area of restoration hotspots. Top 10 countries, ecoregions, conservation.

Fig. 6 PPAR-γ is a direct target of Suv420h.

Fig. 4 Relationships between light and economic parameters.

Fig. 5 Comparison of the liquid products generated from photocatalytic CO2 reduction reactions (CO2RR) and CO reduction reactions (CORR) on two catalysts.

Schematic of the proposed brain-controlled assistive hearing device

Fig. 1 Location of the Jirzankal Cemetery.

Fig. 2 CD4 T cell subset composition in aging.

Fig. 4 CO2 emission changes triggered by the JJJ clean air policy.

Fig. 2 Tissue-specific transcriptomic alterations in response to acute sleep loss in healthy humans. Tissue-specific transcriptomic alterations in response.

Fig. 4 Phase diagram showing significant order parameters ∣pk∣ versus T and wc. Phase diagram showing significant order parameters ∣pk∣ versus T and wc.

Multiplexed four- and eight-channel devices for rapid processing

Fig. 2 Mean field results. Mean field results. (A) Solutions P(x) to Eq. 4 for a range of T and wc = (B) Modulus ∣pk∣ of order parameters versus.

Fig. 4 The relationship between the total mean absolute momentum disturbance 〈∣p∣〉zB (in units of ℏ/D) and fringe visibility V. The relationship between.

Fig. 3 Comparisons of NDVI trends over the globally vegetated areas from 1982 to Comparisons of NDVI trends over the globally vegetated areas from.

Fig. 1 Schematic depiction of a paradigm for rapid and guided discovery of materials through iterative combination of ML with HiTp experimentation. Schematic.

Fig. 4 Mapping of abundance of the most dominant bacterial and archaeal phyla across France. Mapping of abundance of the most dominant bacterial and archaeal.

Fig. 4 Spatial mapping of the distribution and intensity of industrial fishing catch. Spatial mapping of the distribution and intensity of industrial fishing.

Fig. 5 Foxp3 promotes functional recruitment of Bcl11b in Treg cells.

Fig. 1 Quantifying dissonance.

Fig. 5 Density plots showing the relationship between growth responses to extreme events and site-level mean precipitation from all sites (N = 1314). Density.

Fig. 3 Performance of the generative model G, with and without stack-augmented memory. Performance of the generative model G, with and without stack-augmented.

Fig. 4 Behavior of resistance peak near density nm = 5.

Fig. 2 Comparison between the different reflective metasurface proposals when θi = 0° and θr = 70°. Comparison between the different reflective metasurface.

Fig. 3 Gene expression analysis in 48-plex drug treatment experiments.

Fig. 2 Speaker-independent speech separation with ODAN.

Fig. 3 Calculated electronic structure of ZrCoBi.

Fig. 5 Enhancers and super-enhancers identified in various brain cell populations. Enhancers and super-enhancers identified in various brain cell populations.

Fig. 5 CD19-tPSMA(N9del) CAR T cell numbers in mouse and human.

Cxxc1-deficient TH17 cells exhibit a Treg cell–like expression profile

Fig. 2 Time series of secularization versus GDP per capita, from four illustrative countries, over the 20th century. Time series of secularization versus.

Presentation transcript:

Fig. 3 Transcriptional changes in dKO mice. Transcriptional changes in dKO mice. (A) Volcano plot showing the significance of differentially expressed genes in iBAT of dKO versus control mice in RNA-seq Young. The total number of up-regulated (red) and down-regulated (black) genes is shown above the plot. Red dots are considered significant with an adjusted P < 0.1. (B) Network representation of functional enriched biological processes and pathways. Up-regulated genes in dKO were found enriched in several pathways [Enrichr, Fisher Test; false discovery rate (FDR) < 0.05, table S2] and grouped on the basis of the pathways they belong to. Pathways and processes were further grouped into four higher hierarchy super pathways after visually inspecting the clusters. The number of genes contained in each super pathway is shown in parentheses next to the pathway name. (C) Heatmap of normalized (Z score on samples) levels of expression of RT-qPCR–validated genes (in fig. S3) grouped by the three super clusters of interest in (B). Simona Pedrotti et al. Sci Adv 2019;5:eaav1472 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).