A phase II dose-ranging study of the phosphodiesterase inhibitor K-134 in patients with peripheral artery disease and claudication Eric P. Brass, MD,

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A phase II dose-ranging study of the phosphodiesterase inhibitor K-134 in patients with peripheral artery disease and claudication Eric P. Brass, MD, PhD, Leslie T. Cooper, MD, Roger E. Morgan, MD, William R. Hiatt, MD Journal of Vascular Surgery Volume 55, Issue 2, Pages 381-389.e1 (February 2012) DOI: 10.1016/j.jvs.2011.09.004 Copyright © 2012 Society for Vascular Surgery Terms and Conditions

Fig Flow chart shows patient disposition. The modified intention-to-treat (mITT) population included randomized patients who completed the study plus patients who withdrew from the study after a postrandomization treadmill test. AE, Adverse event. *Number of withdrawn patients with postrandomization treadmill results. There were no statistical differences in the withdrawal rates between the placebo, 500-mg K-134, 100-mg K-134, and cilostazol arms using χ2 (P = .429). Journal of Vascular Surgery 2012 55, 381-389.e1DOI: (10.1016/j.jvs.2011.09.004) Copyright © 2012 Society for Vascular Surgery Terms and Conditions